INT224110

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
neurons 2
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 124 100.00 Very High Very High Very High
Kinase C 79 78.72 Quite High
adenocard 60 66.00 Quite High
tetrodotoxin 14 50.28 Quite High
antagonist 19 44.88 Quite Low
Glutamate 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 34.72 Quite Low
Necrosis 1 34.16 Quite Low
Nash(non-alcoholic Steatohepatitis) 12 31.80 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
q/11), suggest that the phosphorylation-dependent activity of endogenous GRK2 is required for M1 mACh receptor desensitization in synaptically-active hippocampal neurons (Willets et al. 2005).
Positive_regulation (required) of Phosphorylation (phosphorylation) of GRK2 in neurons
1) Confidence 0.28 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.28
The role of GRK2 in agonist-induced phosphorylation and subsequent desensitization of A2AR and A2BR was thoroughly investigated by Kelly and co-workers.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GRK2 associated with agonist
2) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.16

General Comments

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