INT22413

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Context Info
Confidence 0.08
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.49
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp39a1) endoplasmic reticulum (Cyp39a1) lipid metabolic process (Cyp39a1)
Anatomy Link Frequency
plasma 1
body 1
Cyp39a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 85.68 High High
Somatostatin 1 24.56 Low Low
Disease Link Frequency Relevance Heat
Hypophosphatemia 12 99.86 Very High Very High Very High
Kidney Stones 11 96.88 Very High Very High Very High
Congenital Anomalies 4 93.68 High High
Rickets 73 91.96 High High
Pain 2 85.68 High High
Disease 11 85.44 High High
Myalgia 1 84.72 Quite High
Diabetes Mellitus 1 77.56 Quite High
Syndrome 5 75.00 Quite High
Nevus 1 59.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that phosphate depletion secondary to antacid abuse caused 1 alpha-hydroxylase activation and elevation of the plasma 1,25-dihydroxyvitamin D level, leading to marked hypercalciuria.
Positive_regulation (activation) of alpha-hydroxylase in plasma associated with kidney stones
1) Confidence 0.08 Published 1990 Journal Aust N Z J Med Section Abstract Doc Link 2291730 Disease Relevance 1.01 Pain Relevance 0.09
Thus, the body responds appropriately to the resultant hypophosphataemia, with stimulation of 1 alpha-hydroxylase activity and a consequent rise in 1,25(OH)2D.
Positive_regulation (stimulation) of alpha-hydroxylase in body associated with hypophosphatemia
2) Confidence 0.04 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.48 Pain Relevance 0

General Comments

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