INT224149

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.44
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 3
Trem1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 98.90 Very High Very High Very High
Inflammation 191 88.00 High High
Inflammatory mediators 2 86.72 High High
agonist 2 83.28 Quite High
cytokine 33 59.68 Quite High
Pain 8 55.52 Quite High
Hyperesthesia 8 44.60 Quite Low
Central nervous system 4 35.20 Quite Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 13 99.84 Very High Very High Very High
Crystal Associated Disease 248 99.00 Very High Very High Very High
INFLAMMATION 200 98.70 Very High Very High Very High
Synovitis 4 89.72 High High
Pneumonia 4 72.96 Quite High
Critical Illness 2 69.76 Quite High
Leukemia 8 65.28 Quite High
Lymphatic System Cancer 8 64.48 Quite High
Hypoxia 1 61.44 Quite High
Nicotine Addiction 2 58.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the time course demonstrated a 79% decrease in TREM-2 mRNA, with a nadir between 9 and 18 hours and subsequent recovery to near baseline level at 50 hours.
Negative_regulation (decrease) of TREM
1) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.43 Pain Relevance 0
The decrease in TREM-2 mRNA in both membranes and cultured macrophages suggests that macrophage activation by MSU crystals leads to an increase in TREM-1 but to a decrease in TREM-2 mRNA levels.
Negative_regulation (decrease) of TREM in macrophages associated with crystal associated disease
2) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.99 Pain Relevance 0.23
TREM-2 is a homologue of TREM-1 that is downregulated during macrophage activation [20], and the microarray analysis had revealed an 81% decrease of its mRNA 9 hours after MSU crystal injection.
Negative_regulation (downregulated) of TREM in macrophage associated with crystal associated disease
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.27 Pain Relevance 0
The decrease in TREM-2 mRNA in both membranes and cultured macrophages suggests that macrophage activation by MSU crystals leads to an increase in TREM-1 but to a decrease in TREM-2 mRNA levels.
Negative_regulation (decrease) of TREM in macrophages associated with crystal associated disease
4) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.79 Pain Relevance 0.12
The biological significance of TREM-1 in acute inflammatory responses is documented in mouse models for septic shock, where competition of TREM-1 with a recombinant soluble TREM-1 fusion protein or an
Negative_regulation (competition) of TREM-1 associated with inflammatory response and sepsis
5) Confidence 0.24 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.97 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox