INT224151

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 13.04
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TREM1) plasma membrane (TREM1) intracellular (TREM1)
Anatomy Link Frequency
fibroblasts 8
monocytes 2
alveolar macrophages 2
TREM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 24 97.60 Very High Very High Very High
Inflammation 177 96.68 Very High Very High Very High
peptic ulcer disease 11 86.32 High High
Inflammatory mediators 24 82.56 Quite High
alcohol 2 68.12 Quite High
corticosteroid 4 62.92 Quite High
Inflammatory response 35 34.44 Quite Low
cytokine 35 13.40 Low Low
cva 12 10.20 Low Low
Angina 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 424 100.00 Very High Very High Very High
Sepsis 119 99.28 Very High Very High Very High
Disease 206 98.80 Very High Very High Very High
Pneumonia 106 98.76 Very High Very High Very High
Asthma 11 97.32 Very High Very High Very High
INFLAMMATION 232 96.68 Very High Very High Very High
Infection 53 95.44 Very High Very High Very High
Airway Obstruction 22 95.20 Very High Very High Very High
Hemophilus Infection 6 90.92 High High
Emphysema 11 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increased levels of sTREM-1 in serum.
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1
1) Confidence 0.52 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.19 Pain Relevance 0.16
ELISA assay could be the reason for increased levels of sTREM-1 detected in the
Positive_regulation (increased) of Gene_expression (detected) of sTREM-1
2) Confidence 0.52 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.10 Pain Relevance 0.21
Concentrations of sTREM-1 and of CRP in sera of both groups and expression of nTREM-1 and mTREM-1 are given in Table 2.
Positive_regulation (Concentrations) of Gene_expression (expression) of nTREM-1
3) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 1.00 Pain Relevance 0.07
In summary we show increased serum levels of sTREM-1
Positive_regulation (levels) of Gene_expression (levels) of sTREM-1
4) Confidence 0.38 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.08 Pain Relevance 0.13
sTREM-1 observed in this group of stable patients with COPD could be persistent
Positive_regulation (observed) of Gene_expression (observed) of sTREM-1 associated with pulmonary disease
5) Confidence 0.38 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.27 Pain Relevance 0.17
In summary we show increased serum levels of sTREM-1
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1
6) Confidence 0.38 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.08 Pain Relevance 0.13
Although it may be hypothesized that Gram-positive cocci and H. influenzae are strong inducers of TREM-1 expression, it should be emphasized that TREM-1 is one PRR, the exact agonist of which remains to be found [29,31].
Positive_regulation (inducers) of Gene_expression (expression) of TREM-1 associated with agonist
7) Confidence 0.37 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.70 Pain Relevance 0.05
ELISA assay could be the reason for increased levels of sTREM-1 detected in the
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1
8) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.10 Pain Relevance 0.21
increased levels of sTREM-1 in patients with sepsis [22], pneumonia [20] but also exacerbated asthma and
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1 associated with asthma, pneumonia and sepsis
9) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.18 Pain Relevance 0.12
In contrast, levels of sTREM-1 in sera of COPD patients were significantly increased (median 11.68 ng/mL, range 6.2–41.9 ng/mL, P<.05).
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1 associated with pulmonary disease
10) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2246041 Disease Relevance 0.62 Pain Relevance 0.04
Serum levels of sTREM-1 are elevated in patients with COPD
Positive_regulation (elevated) of Gene_expression (levels) of sTREM-1 associated with pulmonary disease
11) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.59 Pain Relevance 0
healthy individuals for sTREM-1 and indeed found elevated levels of sTREM-1 in
Positive_regulation (elevated) of Gene_expression (levels) of sTREM-1
12) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.51 Pain Relevance 0.09
levels of sTREM-1 were significantly (P=.019) increased in patients with COPD
Positive_regulation (increased) of Gene_expression (levels) of sTREM-1 associated with pulmonary disease
13) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.63 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of Gene_expression (Expression) of monocytes in fibroblasts
14) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of Gene_expression (patient) of monocytes in fibroblasts
15) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of in monocytes Gene_expression (patient) of monocytes in fibroblasts
16) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of in alveolar macrophages Gene_expression (Expression) of monocytes in fibroblasts
17) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of in alveolar macrophages Gene_expression (patient) of monocytes in fibroblasts
18) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Positive_regulation (for) of in monocytes Gene_expression (Expression) of monocytes in fibroblasts
19) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

General Comments

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