INT224156

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 4.93
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TREM1) plasma membrane (TREM1) intracellular (TREM1)
Anatomy Link Frequency
fibroblasts 8
monocytes 4
alveolar macrophages 2
microglia 2
TREM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 18 98.32 Very High Very High Very High
Inflammation 109 92.88 High High
Inflammatory mediators 17 85.56 High High
agonist 10 82.12 Quite High
chemokine 18 70.72 Quite High
cytokine 43 58.52 Quite High
peptic ulcer disease 5 7.84 Low Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 45 99.26 Very High Very High Very High
Infection 10 98.88 Very High Very High Very High
Disease 100 98.80 Very High Very High Very High
INFLAMMATION 145 98.12 Very High Very High Very High
Emphysema 5 96.76 Very High Very High Very High
Pulmonary Disease 190 93.84 High High
Airway Obstruction 10 93.64 High High
Pneumonia 20 76.88 Quite High
Critical Illness 10 73.68 Quite High
Hypoxia 5 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
limited by low numbers of patients and control sTREM-1 may yet be another
Negative_regulation (limited) of Gene_expression (numbers) of sTREM-1
1) Confidence 0.32 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.15 Pain Relevance 0.13
The biological significance of TREM-1 in acute inflammatory responses is documented in mouse models for septic shock, where competition of TREM-1 with a recombinant soluble TREM-1 fusion protein or an
Negative_regulation (recombinant) of Gene_expression (protein) of soluble TREM-1 associated with inflammatory response and sepsis
2) Confidence 0.32 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.99 Pain Relevance 0.22
Also levels of sTREM-1 in serum were
Negative_regulation (were) of Gene_expression (levels) of sTREM-1
3) Confidence 0.32 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.23 Pain Relevance 0.17
Additionally, we found a correlation of sTREM-1 levels
Negative_regulation (correlation) of Gene_expression (levels) of sTREM-1
4) Confidence 0.32 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.10 Pain Relevance 0.20
medians, and standard deviation (SD) were computed. sTREM-1 levels were compared
Negative_regulation (compared) of Gene_expression (levels) of sTREM-1
5) Confidence 0.32 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.13 Pain Relevance 0
A low level of TREM1 expression in rhesus microglia was confirmed by RT-PCR (data not shown).
Negative_regulation (level) of Gene_expression (expression) of TREM1 in microglia
6) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.33 Pain Relevance 0.18
On the contrary, SLC7A6 gene displayed a well evident expression in AM and fibroblasts, both from controls and LPI, and a very low expression in monocytes.
Negative_regulation (displayed) of Gene_expression (expression) of monocytes in monocytes
7) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of Gene_expression (Expression) of monocytes in fibroblasts
8) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of Gene_expression (patient) of monocytes in fibroblasts
9) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of in monocytes Gene_expression (Expression) of monocytes in fibroblasts
10) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of in alveolar macrophages Gene_expression (patient) of monocytes in fibroblasts
11) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of in monocytes Gene_expression (patient) of monocytes in fibroblasts
12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Negative_regulation (fibroblasts) of in alveolar macrophages Gene_expression (Expression) of monocytes in fibroblasts
13) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

General Comments

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