INT22416

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.41
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 1
nucleus 1
KRT122P (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 8 99.56 Very High Very High Very High
Eae 2 98.44 Very High Very High Very High
tail-flick 6 98.24 Very High Very High Very High
Morphine 6 98.20 Very High Very High Very High
Dopamine 6 98.12 Very High Very High Very High
agonist 2 97.36 Very High Very High Very High
antagonist 10 97.06 Very High Very High Very High
antinociception 14 95.56 Very High Very High Very High
Pain 6 94.08 High High
Opioid 2 92.64 High High
Disease Link Frequency Relevance Heat
Hepatitis 10 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 49 99.64 Very High Very High Very High
Infection 36 99.32 Very High Very High Very High
Hepatitis B Virus Infection 17 99.12 Very High Very High Very High
Dengue 71 98.64 Very High Very High Very High
Pain 2 94.08 High High
Hepatitis C Virus Infection 7 89.40 High High
Hemorrhage 34 86.48 High High
Shock 26 44.48 Quite Low
Thrombocytopenia 6 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that stimulation of the HbC may increase the thresholds of spinally and supraspinally integrated reflexes, thus supporting the hypothesis that this nucleus may play a role in pain control, probably involving an opioid-dependent mechanism.
Positive_regulation (stimulation) of HbC in nucleus associated with pain and opioid
1) Confidence 0.68 Published 1990 Journal Brain Res. Section Abstract Doc Link 2292004 Disease Relevance 0.09 Pain Relevance 0.70
Single brief (15 s), low intensity (53 microA r.m.s.) stimulation of the HbC caused no significant increase in the locomotor activity or motor deficit but induced a potent and short-lasting antinociception as revealed by both algesimetric tests.
Positive_regulation (stimulation) of HbC associated with antinociception and eae
2) Confidence 0.46 Published 1990 Journal Brain Res. Section Abstract Doc Link 2292004 Disease Relevance 0 Pain Relevance 0.46
The effects of intraperitoneal administration of antagonists to morphine, norepinephrine, acetylcholine, dopamine and 5-hydroxytryptamine (5-HT) have been studied on the antinociceptive effect of electrical stimulation of the rat habenular complex (HbC).
Positive_regulation (stimulation) of HbC associated with dopamine, antagonist, antinociceptive and morphine
3) Confidence 0.46 Published 1990 Journal Brain Res. Section Abstract Doc Link 2292024 Disease Relevance 0 Pain Relevance 0.65
A 15-s period of 53 microA rms sine-wave stimulation of the HbC significantly increased the latency of the tail-flick reflex to noxious heat for periods of up to 15 min.
Positive_regulation (stimulation) of HbC in tail associated with tail-flick
4) Confidence 0.46 Published 1990 Journal Brain Res. Section Abstract Doc Link 2292024 Disease Relevance 0 Pain Relevance 0.69
HBC costs are increased in rural areas where a vehicle is required for staff transport.
Positive_regulation (increased) of HBC
5) Confidence 0.34 Published 2002 Journal S. Afr. Med. J. Section Body Doc Link 12244622 Disease Relevance 0 Pain Relevance 0
It is possible that some of these subjects were using HBC services for non-HIV-related conditions as an HIV diagnosis is not required for HBC care.
Neg (not) Positive_regulation (required) of HBC associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.45 Pain Relevance 0.07
Evidence for prior exposure to HBV (antibodies to HBc) was found in 344 (50%) of 694 patients tested, and evidence for chronic HBV infection (antibodies to HBc with positive results for hepatitis B surface antigen and negative results for IgM to HBc) was detected in 69 (11%) of 618 dengue patients and 9 (19%) of 47 OFI patients.
Positive_regulation (results) of HBc associated with dengue, hepatitis b virus infection, hepatitis and infection
7) Confidence 0.04 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.86 Pain Relevance 0

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