INT2242

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.55
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
plasma 2
thyroid 2
sympathetic nervous system 2
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 32 100.00 Very High Very High Very High
Somatostatin 10 99.68 Very High Very High Very High
alcohol 1 99.54 Very High Very High Very High
opiate 2 99.06 Very High Very High Very High
antagonist 13 98.30 Very High Very High Very High
Morphine 4 97.04 Very High Very High Very High
Bile 1 95.80 Very High Very High Very High
addiction 3 95.04 Very High Very High Very High
Catecholamine 2 95.00 High High
peptic ulcer disease 5 94.32 High High
Disease Link Frequency Relevance Heat
Hyperlipidemia 1 99.92 Very High Very High Very High
Peptic Ulcer 5 99.08 Very High Very High Very High
Hypothermia 1 99.04 Very High Very High Very High
Fistula 2 98.94 Very High Very High Very High
Fever 1 98.36 Very High Very High Very High
Hyperkalemia 1 95.96 Very High Very High Very High
Ulcers 20 95.92 Very High Very High Very High
Opiate Addiction 1 95.04 Very High Very High Very High
Hyperplasia 1 95.04 Very High Very High Very High
Duodenal Ulcer 8 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nutrition-related physiological aspects, such as impaired gastrin release, hypercholesterolemia, hypothermia, and hyperthermia, are also seen with morphine use.
Negative_regulation (impaired) of Localization (release) of gastrin associated with hypothermia, fever, hyperlipidemia and morphine
1) Confidence 0.58 Published 1990 Journal J Am Diet Assoc Section Abstract Doc Link 2204648 Disease Relevance 0.72 Pain Relevance 0.78
Interestingly, in contrast to the H2-receptor antagonists, which either increase or have no effect on serum gastrin concentrations, enprostil inhibits basal and postprandial gastrin release.
Negative_regulation (inhibits) of Localization (release) of gastrin associated with antagonist
2) Confidence 0.55 Published 1987 Journal Drugs Section Abstract Doc Link 3121276 Disease Relevance 0.83 Pain Relevance 0.34
While CCK appears to be a negative regulator of gastric acid secretion and postprandial release of gastrin in the normal human gastrointestinal tract, its impact on the pathogenesis of acid hypersecretion in Helicobacter pylori-infected individuals remains uncertain.
Negative_regulation (regulator) of Localization (release) of gastrin associated with ulcers and cholecystokinin
3) Confidence 0.54 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.10 Pain Relevance 0.44
Moreover, enprostil inhibits postprandial gastrin release, whereas H2-blockers increase gastrin levels.
Negative_regulation (inhibits) of Localization (release) of gastrin
4) Confidence 0.53 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940188 Disease Relevance 0.76 Pain Relevance 0.21
On the other hand, plaunotol, an acyclic diterpene alcohol, has been reported to inhibit gastrin release by stimulating endogenous secretion release.
Negative_regulation (inhibit) of Localization (release) of gastrin associated with alcohol
5) Confidence 0.42 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.47 Pain Relevance 0.13
After 4--6 weeks of a full dose cimetidine regimen, both basal and pentagastrin stimulated gastric acid secretion were reduced and peptone meal stimulated serum gastrin increased; the basal gastrinaemia remained unchanged.
Negative_regulation (reduced) of Localization (secretion) of gastrin
6) Confidence 0.42 Published 1979 Journal Acta Hepatogastroenterol (Stuttg) Section Abstract Doc Link 386698 Disease Relevance 0.33 Pain Relevance 0.09
CRF inhibits meal-stimulated gastric acid secretion by activation of the sympathetic nervous system and, in part, by opiate and vasopressin-dependent pathways and not by inhibition of gastrin release.
Negative_regulation (inhibition) of Localization (release) of gastrin in sympathetic nervous system associated with opiate
7) Confidence 0.28 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3544874 Disease Relevance 0.07 Pain Relevance 0.26
CRF significantly (P less than 0.01) inhibited gastric acid secretion, but not plasma gastrin concentrations stimulated by an 8% liquid peptone meal.
Negative_regulation (inhibited) of Localization (secretion) of gastrin in plasma
8) Confidence 0.20 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3544874 Disease Relevance 0.22 Pain Relevance 0.21
In dogs with gastric fistulas and Heidenhain pouches, the lowest dose of CCK that inhibited gastrin-stimulated acid secretion was 674 pmol kg-1 h-1.
Negative_regulation (inhibited) of Localization (secretion) of gastrin associated with fistula and cholecystokinin
9) Confidence 0.16 Published 1979 Journal Gastroenterology Section Abstract Doc Link 447032 Disease Relevance 0.27 Pain Relevance 0.54
Secretin inhibits gastric secretion of acid and gastrin in dog and a physiological role of secretin as an enterogastrone has been suggested in this species.
Negative_regulation (inhibits) of Localization (secretion) of gastrin
10) Confidence 0.16 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2892264 Disease Relevance 0.15 Pain Relevance 0.13
We conclude that in man and dog 95% pure CCK weakly stimulates gastric acid secretion and inhibits gastrin-stimulated acid secretion but these actions occur only with doses of CCK that are maximal or supramaximal for pancreatic enzyme secretion.
Negative_regulation (inhibits) of Localization (secretion) of gastrin associated with cholecystokinin
11) Confidence 0.12 Published 1979 Journal Gastroenterology Section Abstract Doc Link 447032 Disease Relevance 0.26 Pain Relevance 0.51
Somatostatin and octreotide inhibit the release of pituitary and gastro-entero-pancreatic hormones such as growth hormone (GH), thyroid stimulating hormone (TSH), glucagon, cholecystokinin (CCK), vasoactive intestinal peptide (VIP), gastrin, and ghrelin [42–44].
Negative_regulation (inhibit) of Localization (release) of gastrin in thyroid associated with somatostatin and cholecystokinin
12) Confidence 0.05 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 1.36 Pain Relevance 0.59

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