INT224279

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.08
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
sciatic nerve 2
neurons 2
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 68 99.84 Very High Very High Very High
bDMF 219 96.60 Very High Very High Very High
Inflammatory response 24 94.12 High High
ischemia 50 90.84 High High
Spinal cord 110 78.68 Quite High
Inflammation 17 66.00 Quite High
Dorsal column 13 60.48 Quite High
Central nervous system 13 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sciatic Neuropathy 32 99.98 Very High Very High Very High
Apoptosis 49 98.28 Very High Very High Very High
INFLAMMATION 41 93.76 High High
Death 28 93.52 High High
Brain Hemorrhage 3 90.84 High High
Spinal Cord Injury 79 81.76 Quite High
Targeted Disruption 4 80.80 Quite High
Spinal Injuries 6 80.20 Quite High
Stroke 10 66.96 Quite High
Cv Unclassified Under Development 46 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As it is known that sciatic nerve lesion causes upregulation of GAP-43 [75], [76] and phosphorylation of Erk [77], we sought to examine whether endogenous BDNF plays a role in the upregulation of GAP-43 and activated Erk, For this purpose, 8 rats were subjected to the sciatic nerve lesion and 4 rats were treated i.p with either normal sheep serum or the BDNF antiserum as described above.
Positive_regulation (causes) of Positive_regulation (upregulation) of GAP-43 in sciatic nerve associated with sciatic nerve and bdmf
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.45 Pain Relevance 0.42
Others have also reported a parallel increase in a regenerative response post-axotomy, such as an upregulation of Gap43 and an up-regulation of genes involved in apoptosis, usually when axotomy is close to the cell body, and where most axotomized neurons subsequently undergo cell death [65-67].
Positive_regulation (increase) of Positive_regulation (upregulation) of Gap43 in neurons associated with apoptosis and death
2) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 1.28 Pain Relevance 0.05
Although not investigated directly here, BDNF production may be coupled to GAP-43 and synaptophysin inductions in several ways.
Positive_regulation (coupled) of Positive_regulation (inductions) of GAP-43
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

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