INT224280

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.62
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) extracellular region (Bdnf)
nucleolus (Creb1) nucleus (Creb1) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
sensory neurons 1
Bdnf (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 213 100.00 Very High Very High Very High
Spinal cord 90 99.92 Very High Very High Very High
Central nervous system 12 71.72 Quite High
nMDA receptor 3 70.52 Quite High
addiction 9 50.44 Quite High
Inflammation 2 32.84 Quite Low
Sciatic nerve 68 16.80 Low Low
antagonist 7 7.44 Low Low
Dorsal column 13 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 99.52 Very High Very High Very High
Spinal Cord Injury 37 94.32 High High
Aids-related Complex 6 85.12 High High
Injury 32 52.88 Quite High
INFLAMMATION 2 32.84 Quite Low
Sciatic Neuropathy 32 16.80 Low Low
Death 13 5.00 Very Low Very Low Very Low
Nervous System Injury 9 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Contusions 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF may promote the regeneration of sensory neurons by increasing intracellular cAMP and down-stream signal CREB [65].
BDNF Positive_regulation (increasing) of CREB in sensory neurons associated with bdmf
1) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.29 Pain Relevance 0.71
BDNF has been reported to activate transcription factors, such as CREB and NF?
BDNF Positive_regulation (activate) of CREB
2) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.04
BDNF-mediated activation of nuclear transcription factors Elk-1 and CREB is MEK-dependent
BDNF-mediated Positive_regulation (activation) of CREB
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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