INT22429

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 22.58
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PDAP1) signal transduction (PDAP1)
Anatomy Link Frequency
cardiogenic 2
Heart 2
larval hemolymph 1
mitral valve 1
thoracic 1
PDAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 396 99.96 Very High Very High Very High
Angina 5 99.80 Very High Very High Very High
Catecholamine 48 99.76 Very High Very High Very High
anesthesia 56 95.36 Very High Very High Very High
Inflammatory response 13 91.88 High High
ischemia 43 89.20 High High
adenocard 134 89.12 High High
epidural 3 88.72 High High
Arthritis 1 85.96 High High
depression 3 85.44 High High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 49 100.00 Very High Very High Very High
Stable Angina Pectoris 2 99.80 Very High Very High Very High
Cv General 4 Under Development 197 99.76 Very High Very High Very High
Hypoxia 438 99.72 Very High Very High Very High
Tricuspid Valve Insufficiency 65 99.66 Very High Very High Very High
Pulmonary Hypertension 2528 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 572 99.32 Very High Very High Very High
Coronary Artery Disease 11 99.32 Very High Very High Very High
Pulmonary Disease 112 99.16 Very High Very High Very High
Hypotension 351 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some surgical interventions, in particular vascular, cardiac and thoracic surgery may cause acute elevation of PAP either during the surgery or shortly after the intervention has been completed.
Positive_regulation (elevation) of PAP in thoracic
1) Confidence 0.61 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.21 Pain Relevance 0
It is important to emphasize the difference between the ability of RV to adapt to sudden (acute) vs gradual (chronic) elevation of PAP.
Positive_regulation (elevation) of PAP
2) Confidence 0.61 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.51 Pain Relevance 0.03
Pulmonary hypertension is characterized by elevated PAP and secondary RV failure.
Positive_regulation (elevated) of PAP associated with pulmonary hypertension
3) Confidence 0.61 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.20 Pain Relevance 0
Both administration routes prevented a significant increase in mean PAP without severe systemic hypotension (Aubin et al 2008).
Positive_regulation (increase) of PAP associated with hypotension
4) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.88 Pain Relevance 0
Acute arterial pulmonary hypertension is characterized by a sudden increase in PAP.
Positive_regulation (increase) of PAP associated with pulmonary hypertension
5) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.95 Pain Relevance 0.03
Technical difficulties could be related to severe tricuspid regurgitation, RV dilatation, elevated PAP, and decreased cardiac output.
Positive_regulation (elevated) of PAP associated with tricuspid valve insufficiency and cv general 4 under development
6) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.08 Pain Relevance 0
In some circumstances serious and prolonged elevation of PAP progresses to severe acute pulmonary hypertension, leading to life threatening complications including refractory systemic arterial hypotension, severe hypoxemia, RV dysfunction and failure and ultimately resulting in cardiogenic and/or obstructive shock and death.
Positive_regulation (elevation) of PAP in cardiogenic associated with pulmonary hypertension, shock, hypotension and death
7) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.08 Pain Relevance 0
However, in some circumstances serious and prolonged elevation of PAP progresses to severe acute pulmonary hypertension, leading to life threatening complications including refractory systemic arterial hypotension, severe hypoxemia, right ventricular (RV) dysfunction and failure and ultimately resulting in cardiogenic and/or obstructive shock and death.
Positive_regulation (elevation) of PAP in cardiogenic associated with pulmonary hypertension, shock, hypotension and death
8) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.57 Pain Relevance 0
Many complex medical disorders managed in noncardiac ICUs are associated with an elevation of PAP.
Positive_regulation (elevation) of PAP
9) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.98 Pain Relevance 0
Obtaining a PCWP may be technically difficult in patients with markedly elevated PAP, and also carries a high risk of sometimes fatal pulmonary arterial rupture.
Positive_regulation (elevated) of PAP associated with rupture
10) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.08 Pain Relevance 0
It is believed that an elevated PAP during and after surgery develops secondary to acute left heart failure/dysfunction or can be a consequence of pulmonary parenchymal and endothelial injury with activation of the systemic and pulmonary inflammatory response to cardiopulmonary bypass circulation and/or ischemia-reperfusion (Wynne and Botti 2004).
Positive_regulation (elevated) of PAP in heart associated with inflammatory response, cv general 4 under development, ischemia and injury
11) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.95 Pain Relevance 0.09
Inhaled nitroglycerin may be a safer therapeutic option leading to a significant reduction in both mean PAP and PVR in patients after mitral valve operations without reducing systemic mean arterial pressure (Yurtseven et al 2003).
Positive_regulation (mean) of PAP in mitral valve
12) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.86 Pain Relevance 0.08
Many complex medical disorders managed in the intensive care unit (ICU) are associated with an elevation of pulmonary arterial pressure (PAP).
Positive_regulation (elevation) of PAP
13) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.35 Pain Relevance 0
Hemodynamic monitoring during sleep in COPD showed that pulmonary arterial pressure (PAP) increases during hypoxemic episodes (Coccagna et al 1978; Boysen et al 1979; Fletcher et al 1984), and that oxygen administration prevents at the same time desaturations and PAP augmentations (Boysen et al 1979; Fletcher et al 1984).
Positive_regulation (increases) of PAP associated with pulmonary disease
14) Confidence 0.31 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707801 Disease Relevance 0.66 Pain Relevance 0.09
Before excision of the tumor, a larger volume of fluid was transfused than was lost, resulting in the elevation and/or maintenance of pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure (PCWP) at the upper limit of the normal range.
Positive_regulation (elevation) of PAP in upper associated with cancer
15) Confidence 0.24 Published 1990 Journal Proc Chin Acad Med Sci Peking Union Med Coll Section Abstract Doc Link 2293233 Disease Relevance 0.68 Pain Relevance 0.27
0.12) or mean distal segmental PAP both at maximal hyperemia (23±2, 22±2, 22±2, 21±2 mmHg, p?
Positive_regulation (segmental) of PAP associated with increased venous pressure under development
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834756 Disease Relevance 0.22 Pain Relevance 0.06
With regards to the known effect of respiration on hemodynamics, we mitigated mean PAP sampling error by only recording peak mean PAP during each respiratory cycle (occurring at peak expiration in the spontaneously breathing animal)[22].
Positive_regulation (mean) of PAP in respiratory
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834756 Disease Relevance 0.06 Pain Relevance 0
There was no significant effect on SAP, CI (Fig. 1) or calculated SVRI (Fig. 2) with any dose of dopamine, PAP was elevated at all doses, and a significant increase in calculated PVRI was demonstrated only at 10 ?
Positive_regulation (elevated) of PAP associated with dopamine
18) Confidence 0.23 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.46 Pain Relevance 0.25
Dopamine had no effect on CI, SAP, and SVRI, but increased PAP at all doses and PVRI at 32 ?
Neg (no) Positive_regulation (increased) of PAP associated with dopamine
19) Confidence 0.23 Published 2001 Journal Crit Care Section Abstract Doc Link PMC31580 Disease Relevance 0.32 Pain Relevance 0.30
There was no significant effect on SAP, CI (Fig. 1) or calculated SVRI (Fig. 2) with any dose of dopamine, PAP was elevated at all doses, and a significant increase in calculated PVRI was demonstrated only at 10 ?
Positive_regulation (increase) of PAP associated with dopamine
20) Confidence 0.23 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.46 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox