INT224298

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.29
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2) endoplasmic reticulum (PSEN2) embryo development (PSEN2)
protein complex (PSEN2) cytosol (PSEN2) peptidase activity (PSEN2)
PSEN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 52 97.60 Very High Very High Very High
Inflammation 21 89.40 High High
Eae 10 65.08 Quite High
addiction 10 28.32 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
Rsd 12 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 144 99.32 Very High Very High Very High
Disease 29 99.20 Very High Very High Very High
Infection 17 93.40 High High
INFLAMMATION 23 89.40 High High
Targeted Disruption 23 85.36 High High
Apoptosis 84 84.72 Quite High
Sprains And Strains 27 79.44 Quite High
Cervical Cancer 26 76.24 Quite High
Breast Cancer 66 50.00 Quite Low
Alzheimer's Dementia 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evidence that mutations in PSEN1/PSEN2 that cause Familial Alzheimer's disease are loss of function mutants, and that loss of PSEN1/PSEN2 function causes neurodegeneration in mice, supports this hypothesis [49], [50], [51], [52], [53].
Negative_regulation (loss) of PSEN2 associated with disease
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.87 Pain Relevance 0.03
None of the analyzed reagents (dexamethasone, salicylic acid and sodium salicylate) caused significant cell killing on their own or in combination with replication deficient E1-deleted Ad5luc1 (Fig. 4a, e).
Negative_regulation (deficient) of Ad5 associated with dexamethasone
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.52 Pain Relevance 0.25
The cell growth assay reinforced findings in Fig. 2 that growth inhibition of Ad5CMV-p53-infected tumor cells was more significant, compared with the cells infected with only the viral vector Ad5CMV or only PBS (Fig. 3).


Negative_regulation (inhibition) of Ad5 associated with cancer
3) Confidence 0.41 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.76 Pain Relevance 0
mRNA level, the pS2 mRNA level was only modestly decreased by decursin or DA.
Negative_regulation (decreased) of pS2
4) Confidence 0.19 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
and pS2 mRNA levels were not decreased by decursinol treatment (Figure 5c, lanes 7 and 8 versus lane 2).
Neg (not) Negative_regulation (decreased) of pS2
5) Confidence 0.19 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
A marked and concentration-dependent impairment of pS1 and pS2 activities could be detected in the presence of ppGpp.
Negative_regulation (impairment) of pS2
6) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.06 Pain Relevance 0
Positions corresponding to pB, pS1 and pS2 transcription start sites are shown

The pS1 and pS2 promoters are negatively regulated by ppGpp and DksA in vitro

Negative_regulation (sites) of pS2
7) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.08 Pain Relevance 0

General Comments

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