INT2243

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Context Info
Confidence 0.81
First Reported 1979
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 67
Total Number 68
Disease Relevance 34.54
Pain Relevance 16.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
capsule 3
gum 3
lung 3
glands 3
plasma 2
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 74 100.00 Very High Very High Very High
Serotonin 18 100.00 Very High Very High Very High
Somatostatin 159 99.92 Very High Very High Very High
qutenza 18 99.92 Very High Very High Very High
Neuropeptide 69 99.72 Very High Very High Very High
Morphine 10 99.66 Very High Very High Very High
Enkephalin 28 99.64 Very High Very High Very High
narcan 10 99.40 Very High Very High Very High
alcohol 43 99.38 Very High Very High Very High
antagonist 27 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 313 99.96 Very High Very High Very High
Hyperlipidemia 1 99.92 Very High Very High Very High
Gastrinoma 62 99.84 Very High Very High Very High
Lung Cancer 17 99.68 Very High Very High Very High
Hypercalcemia 45 99.64 Very High Very High Very High
Duodenal Ulcer 35 99.36 Very High Very High Very High
Hypoxia 11 99.04 Very High Very High Very High
Hypothermia 1 99.04 Very High Very High Very High
Fistula 7 98.74 Very High Very High Very High
Nicotine Addiction 51 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies demonstrate that a placebo capsule, administered by a physician just prior to a meal, has little, if any, effect on acid secretion or gastrin release in response to the meal.
Localization (secretion) of gastrin in capsule
1) Confidence 0.81 Published 1988 Journal Dig. Dis. Sci. Section Abstract Doc Link 3338362 Disease Relevance 0.32 Pain Relevance 0.09
The effect of a synthetic met-enkephalin analogue (FK 33-824) on gastric acid secretion and serum gastrin in man.
Localization (secretion) of gastrin associated with enkephalin
2) Confidence 0.80 Published 1981 Journal Scand. J. Gastroenterol. Section Title Doc Link 7323691 Disease Relevance 0 Pain Relevance 0.76
Furthermore, various lung cancers synthesize and release a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES), because of a lung tumor, has never been described.
Localization (release) of gastrin in lung associated with lung cancer and syndrome
3) Confidence 0.80 Published 2001 Journal Gastroenterology Section Abstract Doc Link 11266390 Disease Relevance 1.56 Pain Relevance 0.20
Nutrition-related physiological aspects, such as impaired gastrin release, hypercholesterolemia, hypothermia, and hyperthermia, are also seen with morphine use.
Localization (release) of gastrin associated with hypothermia, fever, hyperlipidemia and morphine
4) Confidence 0.80 Published 1990 Journal J Am Diet Assoc Section Abstract Doc Link 2204648 Disease Relevance 0.72 Pain Relevance 0.78
These findings suggest that plaunotol may suppress hypergastrinemia induced by long-term omeprazole administration, at least partly, via a certain brain-gut hormone affecting gastrin release.
Localization (release) of gastrin in gut
5) Confidence 0.79 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.55 Pain Relevance 0.14
On the other hand, plaunotol, an acyclic diterpene alcohol, has been reported to inhibit gastrin release by stimulating endogenous secretion release.
Localization (release) of gastrin associated with alcohol
6) Confidence 0.79 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.47 Pain Relevance 0.13
The secretory studies showed an increase in release of gastrin and somatostatin compared to the control vials (P = 0.003; P = 0.013).
Localization (release) of gastrin
7) Confidence 0.78 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
A chilli-rich diet had an inhibitory effect on gastrin release upon stimulation compared to the results that were obtained before the start of the diet.
Localization (release) of gastrin
8) Confidence 0.78 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
AIM: To identify VR1-expressing endocrine-like cells in human antral glands and to examine whether stimulation with capsaicin causes release of gastrin, somatostatin, and serotonin.
Localization (release) of gastrin in glands
9) Confidence 0.78 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This study shows that capsaicin stimulates gastrin secretion from isolated human antral glands, and that a chilli-rich diet decreases this secretion.


Localization (secretion) of gastrin in glands
10) Confidence 0.78 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
Cardiac output (QT) was determined by thermodilution, and the distribution of blood flow between the lungs was assessed from the excretion of a continuously infused, poorly soluble gas (SF6).
Localization (excretion) of gas in lungs
11) Confidence 0.78 Published 1987 Journal Anesthesiology Section Abstract Doc Link 3826689 Disease Relevance 0.56 Pain Relevance 0.44
Cardiac output was determined by thermodilution, and the distribution of blood flow between the lungs was assessed from the excretion of a continuously infused poorly soluble gas (SF6).
Localization (excretion) of gas in blood
12) Confidence 0.78 Published 1985 Journal Anesthesiology Section Abstract Doc Link 3994027 Disease Relevance 0.41 Pain Relevance 0.16
Interestingly, in contrast to the H2-receptor antagonists, which either increase or have no effect on serum gastrin concentrations, enprostil inhibits basal and postprandial gastrin release.
Localization (release) of gastrin associated with antagonist
13) Confidence 0.75 Published 1987 Journal Drugs Section Abstract Doc Link 3121276 Disease Relevance 0.82 Pain Relevance 0.34
Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humans.
Localization (secretion) of gastrin associated with narcan and morphine
14) Confidence 0.75 Published 1980 Journal Gastroenterology Section Title Doc Link 7399233 Disease Relevance 0.07 Pain Relevance 1.04
Furthermore, various lung cancers synthesize and release a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES), because of a lung tumor, has never been described.
Localization (releasing) of gastrin in lung associated with lung cancer and syndrome
15) Confidence 0.75 Published 2001 Journal Gastroenterology Section Abstract Doc Link 11266390 Disease Relevance 1.57 Pain Relevance 0.20
While CCK appears to be a negative regulator of gastric acid secretion and postprandial release of gastrin in the normal human gastrointestinal tract, its impact on the pathogenesis of acid hypersecretion in Helicobacter pylori-infected individuals remains uncertain.
Localization (release) of gastrin associated with ulcers and cholecystokinin
16) Confidence 0.74 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.10 Pain Relevance 0.43
Physiologic recognition of the roles of vagal stimulation and antral gastrin in the secretion of acid from the stomach resulted in the development of the operation of vagotomy and antrectomy for peptic ulcer disease.
Localization (secretion) of gastrin in stomach associated with peptic ulcer disease and disease
17) Confidence 0.74 Published 1990 Journal Surg Gynecol Obstet Section Abstract Doc Link 2152987 Disease Relevance 0.54 Pain Relevance 0.22
In our results, however, we could not detect any differences in serum gastrin concentration which has been known as a major hormone regulating secretion of gastric juice.
Localization (secretion) of gastrin in gastric juice
18) Confidence 0.73 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808598 Disease Relevance 0.43 Pain Relevance 0
Moreover, enprostil inhibits postprandial gastrin release, whereas H2-blockers increase gastrin levels.
Localization (release) of gastrin
19) Confidence 0.73 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940188 Disease Relevance 0.76 Pain Relevance 0.21
Effect of oral nalmefene, an opiate-receptor antagonist, on meal-stimulated gastric acid secretion and serum gastrin concentration in man.
Localization (secretion) of gastrin associated with antagonist and opiate
20) Confidence 0.71 Published 1985 Journal Regul. Pept. Section Title Doc Link 4059587 Disease Relevance 0 Pain Relevance 0.39

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