INT224305

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (KDR, VEGFA) extracellular region (KDR, VEGFA) extracellular space (VEGFA)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) nucleus (KDR)
KDR (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 57.76 Quite High
cytokine 3 20.56 Low Low
addiction 3 18.12 Low Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 111 75.04 Quite High
INFLAMMATION 4 57.76 Quite High
Breast Cancer 44 53.64 Quite High
Malignant Neoplastic Disease 2 30.00 Quite Low
Hypoxia 19 27.76 Quite Low
Disease 11 10.40 Low Low
Peripheral Arterial Disease 18 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 6 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for the soluble species, total free VEGF in all compartments decreased with increasing VEGF-binding affinity of either VEGFR1 or VEGFR2 – presumably through enhanced internalization of complexed VEGF (Fig. 6B).
Positive_regulation (increasing) of VEGFR2 Binding (affinity) of VEGF-binding
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The neuropilins bind not only class 3 semaphorins, which are involved in axonal growth, but also some isoforms of VEGF, where they function as co-receptors, increasing VEGF binding to VEGFR2 [86].
Positive_regulation (increasing) of VEGFR2 Binding (binding) of VEGF
2) Confidence 0.22 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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