INT22431

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 29
Disease Relevance 6.60
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
blood 3
erythrocyte 1
margin 1
vesicles 1
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 67 97.08 Very High Very High Very High
lidocaine 33 95.68 Very High Very High Very High
analgesia 13 92.60 High High
Paracetamol 17 91.12 High High
local anesthetic 72 89.68 High High
headache 2 87.92 High High
Angina 1 84.56 Quite High
nerve block 30 81.56 Quite High
Pain 35 70.24 Quite High
depression 1 58.92 Quite High
Disease Link Frequency Relevance Heat
Methemoglobinemia 279 99.60 Very High Very High Very High
Hypoxia 14 93.48 High High
Cyanosis 73 90.32 High High
Headache 2 87.92 High High
Vomiting 4 87.12 High High
Diarrhoea 2 85.68 High High
Toxicity 14 85.44 High High
Body Weight 11 84.92 Quite High
Cv General 3 Under Development 1 84.56 Quite High
Reprotox - General 3 10 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preoperative iv administration of 1 mg.kg(-1) of methylene blue resulted, within five minutes, in a decrease of methemoglobin fraction down to 0.05 associated with an increase of the fractional oxyhemoglobin saturation up to 94.7%.
Negative_regulation (decrease) of methemoglobin
1) Confidence 0.58 Published 2005 Journal Can J Anaesth Section Body Doc Link 15753496 Disease Relevance 0.08 Pain Relevance 0
Although the predominant intracellular mechanism for the reduction of methemoglobin is cytochrome b5, adult levels of the enzyme are reached by 2 to 3 months of age.
Negative_regulation (reduction) of methemoglobin
2) Confidence 0.56 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.35 Pain Relevance 0.09
The finding of decreased methemoglobin levels with increasing gestational age is not unique to this study.
Negative_regulation (decreased) of methemoglobin
3) Confidence 0.56 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The prophylactic preoperative methylene blue administration in a patient with congenital methemoglobinemia significantly decreased the methemoglobin level and increased the fractional oxygen saturation with a consequent increase of the safety margin against perioperative hypoxemia.


Negative_regulation (decreased) of methemoglobin in margin
4) Confidence 0.50 Published 2005 Journal Can J Anaesth Section Body Doc Link 15753496 Disease Relevance 0.05 Pain Relevance 0
The methemoglobin concentration already showed a decrease 360 min after the application of the regional anesthetic 2,000 mg ascorbic acid given intravenously before plexus anesthesia was not able to influence the resulting methemoglobin concentrations.
Negative_regulation (decrease) of methemoglobin
5) Confidence 0.43 Published 2003 Journal Anaesthesist Section Body Doc Link 14992088 Disease Relevance 0 Pain Relevance 0
After two hours, the methemoglobin fraction decreased to 0.01 and the fractional oxyhemoglobin concentration increased to 97.7%.
Negative_regulation (decreased) of methemoglobin
6) Confidence 0.43 Published 2005 Journal Can J Anaesth Section Body Doc Link 15753496 Disease Relevance 0.07 Pain Relevance 0
[Does the development of methemoglobin in the newborn infant affect the suitability of prilocaine for pudendal anesthesia?
Negative_regulation (development) of methemoglobin associated with anesthesia
7) Confidence 0.43 Published 1989 Journal Reg Anaesth Section Title Doc Link 2772273 Disease Relevance 0.36 Pain Relevance 0.44
Reduction of methemoglobin is usually complete within 1 hour.
Negative_regulation (Reduction) of methemoglobin
8) Confidence 0.42 Published 2006 Journal Bol Asoc Med P R Section Abstract Doc Link 19606800 Disease Relevance 0.94 Pain Relevance 0.27
Postoperatively, the methemoglobin fractions remained low for 24 hr, to be followed by a gradual increase up to 0.02 on the second day to reach 0.094 on the fifth day.
Negative_regulation (followed) of methemoglobin
9) Confidence 0.42 Published 2005 Journal Can J Anaesth Section Body Doc Link 15753496 Disease Relevance 0.06 Pain Relevance 0
The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase deficiency.
Negative_regulation (deficiency) of methemoglobin associated with methemoglobinemia
10) Confidence 0.42 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2293580 Disease Relevance 0.17 Pain Relevance 0.09
He was diagnosed as having methemoglobinemia; underlying erythrocyte-methemoglobin reductase deficiency and glucose-6-phosphate dehydrogenase deficiency were ruled out and 1 mg/kg methylene blue was given intravenously.
Negative_regulation (deficiency) of methemoglobin reductase in erythrocyte associated with methemoglobinemia
11) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.73 Pain Relevance 0.16
The predominant intracellular mechanism for the reduction of methemoglobin is cytochrome b5, and only 1 to 2% of hemoglobin is normally in the ferric state.
Negative_regulation (reduction) of methemoglobin
12) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.58 Pain Relevance 0.70
Under physiological conditions, methemoglobin reduction is accomplished mainly by red cell nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase (NADH-methemoglobin reductase) thus ensuring that there are insignificant amounts of methemoglobin in the circulating blood.
Negative_regulation (reduction) of methemoglobin in blood
13) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.41 Pain Relevance 0.09
Although under physiological conditions, ascorbic acid-induced methemoglobin reduction is less important than reduction by the NADP-dependent methemoglobin reductase system, under methemoglobinemic conditions, treatment with ascorbic acid is possible.
Negative_regulation (reduction) of methemoglobin
14) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.38 Pain Relevance 0.22
Pregnant women showed a decrease in methemoglobin levels with increasing gestation although <1% had levels above the physiologic normal of 2% methemoglobin, regardless of the source of their drinking water.
Negative_regulation (decrease) of methemoglobin
15) Confidence 0.42 Published 2010 Journal Environ Health Section Abstract Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
However, previous reports have indicated that vitamins C and E can reduce methemoglobin levels [53,54], and both are commonly found in multivitamin preparations taken during pregnancy.
Negative_regulation (reduce) of methemoglobin
16) Confidence 0.42 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
The current study result of decreasing methemoglobin levels during pregnancy did not support the a priori hypothesis that methemoglobin levels increase during pregnancy in populations exposed to nitrates in drinking water.
Negative_regulation (decreasing) of methemoglobin
17) Confidence 0.42 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.06 Pain Relevance 0
The potential effects of vitamin rich vegetables on reducing methemoglobin level or on a woman's ability to reduce methemoglobin back to hemoglobin, is a factor also to be considered given the low levels of methemoglobin observed.
Negative_regulation (reducing) of methemoglobin
18) Confidence 0.42 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
The longitudinal assessment showed decreasing methemoglobin levels with increasing gestational age.
Negative_regulation (decreasing) of methemoglobin
19) Confidence 0.42 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.08 Pain Relevance 0
It directly reduces methemoglobin but the rate is too slow for it to be effective [13].
Negative_regulation (reduces) of methemoglobin
20) Confidence 0.41 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.33 Pain Relevance 0.20

General Comments

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