INT224325

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FLT1) endosome (FLT1) Golgi apparatus (FLT1)
cytoplasm (FLT1) extracellular space (FLT1) extracellular region (FLT1)
Anatomy Link Frequency
blood 2
FLT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1 15.04 Low Low
metalloproteinase 8 10.96 Low Low
headache 2 5.60 Low Low
Pain 1 5.20 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 46 97.82 Very High Very High Very High
Pre-eclampsia 39 93.12 High High
Solid Tumor 3 88.56 High High
Metastasis 4 86.60 High High
Cancer 116 85.72 High High
Carcinoma 1 51.28 Quite High
Fibromyalgia 5 50.00 Quite Low
Disease 26 45.80 Quite Low
Disease Susceptibility 1 40.56 Quite Low
Advanced Or Metastatic Breast Cancer 6 36.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, decreased Flt-1 expression has been shown in the placental bed of preeclamptic patients [27].
Negative_regulation (decreased) of Gene_expression (expression) of Flt-1
1) Confidence 0.57 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.23 Pain Relevance 0
Therefore, in the absence of sVEGFR1 expression, the control VEGF-secretion rates necessary to achieve the targeted [V]pl of 1.5 pM, as well as symmetric [V]IS (i.e., 15 pM in both “calf” and “normal” interstitia), would have been qV,-Ctrl?
Negative_regulation (absence) of Gene_expression (expression) of sVEGFR1
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
These primary effects in blood in turn were propagated into the interstitium through permeability, i.e., via reduced net sVEGFR1 extravasation and upregulated net VEGF intravasation.
Negative_regulation (reduced) of Gene_expression (extravasation) of sVEGFR1 in blood
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
However, a phase II trial in breast cancer provided no evidence of clinical activity [111], although there was evidence of biological activity, with a decrease in serum VEGFR1 levels.
Negative_regulation (decrease) of Gene_expression (levels) of VEGFR1 associated with breast cancer
4) Confidence 0.31 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.62 Pain Relevance 0

General Comments

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