INT224326

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.11
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 5 52.80 Quite High
metalloproteinase 6 40.04 Quite Low
Glutamate 1 37.88 Quite Low
tolerance 1 33.12 Quite Low
Antihistamine 1 13.36 Low Low
vincristine 1 9.44 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 99.80 Very High Very High Very High
Cancer 187 99.32 Very High Very High Very High
Disease 61 98.36 Very High Very High Very High
Non-small-cell Lung Cancer 5 93.72 High High
Renal Cancer 2 93.52 High High
Reprotox - General 1 2 91.96 High High
Ovarian Cancer 2 90.52 High High
Colon Cancer 3 89.88 High High
Disease Progression 1 89.40 High High
Gastrointestinal Stromal Tumor 1 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The raf-1/MEK/ERK pathway has long been recognized for its role in cancer biology.
raf-1 Binding (recognized) of associated with cancer
1) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.28 Pain Relevance 0
Another raf-1 As-ODN, LErafAON (NeoPharm), a 15-mer As-ODN directed to the translation initiation site of c-raf-1 mRNA, has also entered clinical trials.
raf-1 Binding (entered) of
2) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.18 Pain Relevance 0.05
It was selected for further pharmacological characterization based on potent inhibition of Raf-1 and its favourable kinase selectivity profile.
Raf-1 Neg (inhibition) Binding (inhibition) of
3) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.65 Pain Relevance 0

General Comments

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