INT224327

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.29
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
tears 1
endothelial cells 1
apoptotic cells 1
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 81.28 Quite High
imagery 9 80.88 Quite High
rheumatoid arthritis 2 42.08 Quite Low
Osteoarthritis 3 12.32 Low Low
Pain 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 190 99.64 Very High Very High Very High
Apoptosis 21 99.52 Very High Very High Very High
Death 15 97.68 Very High Very High Very High
Rupture 2 96.00 Very High Very High Very High
Hypoxia 36 93.76 High High
Increased Venous Pressure Under Development 2 93.24 High High
Renal Cell Carcinoma 30 91.68 High High
Carcinoma 6 90.28 High High
Disease 66 87.52 High High
Tendinopathy 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Benson et al. showed HIF levels to be high in mild impingement, small, medium, and large tears, but reduced in massive tears.
Negative_regulation (reduced) of HIF in tears
1) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.56 Pain Relevance 0
Their unique action is attributed to their effect directly on the tumor cells themselves, in part due to HIF downregulation, and on tumor endothelial cells by blocking proliferation and survival signals downstream of the VEGF receptor.23–25 One study has also shown that the benefits of mTOR inhibition may be greater in papillary renal carcinoma than in clear cell carcinoma; papillary subtype accounting for 10% to 15% of renal cell cancers.26 This is postulated to be due to HIF upregulation which is noted in patients with papillary renal cell carcinoma associated with fumarate–hydratase mutations.27
Negative_regulation (downregulation) of HIF in endothelial cells associated with cancer, carcinoma and renal cell carcinoma
2) Confidence 0.08 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.86 Pain Relevance 0
and the co-activator CBP/p300 led to attenuation of HIF-induced gene expression and inhibition of tumour growth in a xenograft model [42].
Negative_regulation (attenuation) of HIF associated with cancer
3) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.87 Pain Relevance 0
inhibitors of HIF and/or its downstream targets [13].
Negative_regulation (inhibitors) of HIF
4) Confidence 0.02 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.54 Pain Relevance 0.04
It was also noted that in the tumours of DPQ-treated mice, there were increased apoptotic cells, suggesting that inhibition of Hif-1?
Negative_regulation (inhibition) of Hif in apoptotic cells associated with cancer and apoptosis
5) Confidence 0.01 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 1.47 Pain Relevance 0.04

General Comments

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