INT224332

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX2) oxidoreductase activity (HMOX2) endoplasmic reticulum (HMOX2)
plasma membrane (HMOX2) transmembrane transport (HMOX2)
Anatomy Link Frequency
macrophages 1
HMOX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 96.96 Very High Very High Very High
cytokine 2 68.80 Quite High
Potency 1 61.32 Quite High
methotrexate 3 33.84 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 106 99.80 Very High Very High Very High
Necrosis 2 99.52 Very High Very High Very High
Hypoxia 18 99.36 Very High Very High Very High
Breast Cancer 42 98.86 Very High Very High Very High
Metastasis 4 90.64 High High
Apoptosis 3 83.84 Quite High
Advanced Or Metastatic Breast Cancer 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Solid Tumor 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAMs are recruited to avascular areas in breast tumours probably through hypoxic stimulation, in which they can release a variety of potent angiogenic factors, including VEGF (itself a chemoattractant for macrophages), thymidine phosphorylase, cyclo-oxygenase-2 and tumour necrosis factor-?.
Localization (release) of cyclo-oxygenase-2 in macrophages associated with necrosis, cancer, hypoxia and breast cancer
1) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 1.15 Pain Relevance 0.11

General Comments

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