INT224335

Context Info Confidence 0.35 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 5.24 Pain Relevance 0.09

extracellular region (KDR) cytoplasmic membrane-bounded vesicle (KDR) plasma membrane (KDR) nucleus (KDR) cytoplasm (KDR)

Anatomy Link Frequency internal 4 KDR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 8 99.40 imagery 2 25.44 headache 4 18.40 Pain 2 18.00 methotrexate 3 14.88 dexamethasone 17 5.00 cytokine 8 5.00 Central nervous system 3 5.00 fibrosis 3 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Cancer 179 100.00 Myeloid Leukemia 25 99.84 Acute Myeloid Leukemia 22 99.84 Inflammatory Breast Neoplasms 3 99.68 Apoptosis 10 99.20 Myelodysplastic Syndromes 29 93.36 Advanced Or Metastatic Breast Cancer 23 88.44 INFLAMMATION 6 87.04 Appetite Loss 3 83.28 Myelofibrosis 21 82.72

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Anatomy

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Speculation

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Disease term

Vatalanib decreased VEGF levels and VEGFR phosphorylation in AML cells, which showed FLT3 internal tandem reduplications/mutations (ITD), raising the question of the actual targeted tyrosine kinase (VEGFR or flt3).

Negative_regulation (decreased) of Phosphorylation (phosphorylation) of VEGFR in internal associated with myeloid leukemia

1) Confidence 0.35 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.72 Pain Relevance 0

Furthermore, a pilot study conducted in patients with inflammatory breast cancer demonstrated a decrease in tumour cell VEGFR2 (KDR) phosphorylation and an increase in apoptosis after a single cycle of bevacizumab therapy.

Negative_regulation (decrease) of Phosphorylation (phosphorylation) of VEGFR2 associated with inflammation, cancer and apoptosis

2) Confidence 0.29 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.71 Pain Relevance 0.05

Vatalanib decreased VEGF levels and VEGFR phosphorylation in AML cells, which showed FLT3 internal tandem reduplications/mutations (ITD), raising questions about the actual targeted tyrosine kinase (VEGFR of flt3).

Negative_regulation (decreased) of Phosphorylation (phosphorylation) of VEGFR in internal associated with acute myeloid leukemia

3) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.83 Pain Relevance 0

PTPi I and PTPi II have both been shown to be potent inhibitors of Shp1, a phosphatase which inhibits VEGFR2 phosphorylation, and hence is a negative signaling component (36).

Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of VEGFR2

4) Confidence 0.10 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.12 Pain Relevance 0

A median decrease of 66.7% in phosphorylated VEGFR in tumor cells (p = 0.004) and a median increase of 128.9% in tumor apoptosis (p = 0.0008) were seen after bevacizumab alone.

Negative_regulation (decrease) of Phosphorylation (phosphorylated) of VEGFR associated with cancer and apoptosis

5) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721345 Disease Relevance 0.86 Pain Relevance 0.04

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