INT22434

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 9.16
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
brain 1
Ads1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 12 100.00 Very High Very High Very High
5HT 3 97.00 Very High Very High Very High
noradrenaline 3 96.84 Very High Very High Very High
Arthritis 14 93.64 High High
depression 1 89.44 High High
Angina 4 86.32 High High
Serotonin 1 84.24 Quite High
monoamine 1 75.64 Quite High
corticosteroid 8 74.36 Quite High
methotrexate 8 73.68 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 175 100.00 Very High Very High Very High
Herpes Simplex Virus 3 99.96 Very High Very High Very High
Cancer 669 99.70 Very High Very High Very High
Proteinuria 10 99.68 Very High Very High Very High
Systemic Lupus Erythematosus 624 99.42 Very High Very High Very High
Glioma 69 98.88 Very High Very High Very High
Skin Cancer 1 98.76 Very High Very High Very High
Infection 61 98.44 Very High Very High Very High
Disease 216 97.32 Very High Very High Very High
Carcinoma 9 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tacrolimus was more effective in improving proteinuria and inhibiting anti-dsDNA antibody production with a reduced incidence of pulmonary infections.35 Another small study with a total of 60 patients showed comparable efficacy of MMF, tacrolimus, and intravenous cyclophosphamide in lupus nephritis regarding complete remission.36 Phase III trials with tacrolimus or a combination of tacrolimus and MMF have already been completed or are recruiting (www.ClinicalTrials.gov) and results should be available soon.


Gene_expression (production) of anti-dsDNA antibody associated with renal disease, proteinuria and infection
1) Confidence 0.75 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 1.05 Pain Relevance 0
At baseline, 90% of the patients had ANA titers of 1:40 or greater, 60% were anti-dsDNA antibody positive (?
Gene_expression (positive) of anti-dsDNA antibody
2) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.54 Pain Relevance 0.08
We also measured the serum levels of two autoimmunity-related antibodies, namely, anti-nuclear antibody (ANA) and anti-dsDNA antibody.
Gene_expression (levels) of anti-dsDNA antibody associated with autoimmune disease
3) Confidence 0.58 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.79 Pain Relevance 0.03
Lithium may also facilitate the expression of antidepressant activity of ADS not active by themselves in the FST.
Gene_expression (expression) of ADS associated with antidepressant
4) Confidence 0.51 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862913 Disease Relevance 0.09 Pain Relevance 0.92
To uncover the role of TLR signaling in brain tumor regression and immunological memory, we developed a syngeneic, intracranial mouse glioma model; treatment consisted of intratumoral delivery of Ads expressing Flt3L and TK (Ad-TK + Ad-Flt3L), followed by systemic delivery of GCV.
Gene_expression (expressing) of Ads in brain associated with glioma and brain tumor
5) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.56 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (generation) of Ads associated with herpes simplex virus
6) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.85 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (expressing) of Ads associated with herpes simplex virus
7) Confidence 0.09 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.84 Pain Relevance 0
Microbial DNA (bacterial and viral) is a known immunogen and some authors suggest that a high frequency of unmethylated CpG motifs in microbial DNA acts as a stimulator of anti-DNA antibody production and the flare of symptoms seen in lupus.
Gene_expression (production) of anti-DNA antibody associated with systemic lupus erythematosus
8) Confidence 0.05 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.28 Pain Relevance 0
The precise mechanisms leading to anti-DNA antibody production remain unknown.
Gene_expression (production) of anti-DNA antibody
9) Confidence 0.05 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.75 Pain Relevance 0
All the tumors were variably positive for anti-keratin antibody AE1 and AE3, but negative for AE2.
Neg (negative) Gene_expression (positive) of anti-keratin antibody AE1 associated with cancer
10) Confidence 0.04 Published 1990 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 2294778 Disease Relevance 1.56 Pain Relevance 0.09
Idiotypic vaccines developed anti-DNA antibody vaccines in mice.
Gene_expression (vaccines) of anti-DNA antibody
11) Confidence 0.04 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.79 Pain Relevance 0.11
Thus, both anti-dsDNA and anti-ssDNA fractions were obtained and analyzed for their hydrolytic activity, either separately or together.
Spec (analyzed) Gene_expression (fractions) of anti-ssDNA
12) Confidence 0.04 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.12 Pain Relevance 0
Gololobov et al. [42, 43] and Rodkey et al. [30] used a modification of this approach to purify the mouse monoclonal anti-ssDNA antibody and its Fab fragment (obtained by papain hydrolysis) with excellent results with respect to their activity.
Gene_expression (antibody) of anti-ssDNA
13) Confidence 0.03 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0 Pain Relevance 0
Teodorescu [5] performed a longitudinal clinical study in a group of lupus patients and concluded that levels of anti-ss-DNA autoantibodies are the best predictors of a forthcoming increase in dsDNA levels and the SLE symptom flare.
Gene_expression (levels) of anti-ss-DNA associated with systemic lupus erythematosus
14) Confidence 0.03 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.72 Pain Relevance 0
Furthermore, the anti-phosphoTRPV1 antibody detected phosphorylation of TRPV1 in mouse and rat DRG neurons and may be useful for research regarding nociception in native tissues.
Gene_expression (detected) of anti-phosphoTRPV1 in neurons associated with nociception
15) Confidence 0.00 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.18

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