INT224366

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 111
Total Number 113
Disease Relevance 125.37
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
heart 22
mononuclear phagocytes 12
lung 10
endothelial cells 6
T lymphocytes 4
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 444 99.80 Very High Very High Very High
fibrosis 150 99.78 Very High Very High Very High
Inflammation 2458 99.32 Very High Very High Very High
Inflammatory response 156 99.00 Very High Very High Very High
Osteoarthritis 74 98.04 Very High Very High Very High
cytokine 711 97.92 Very High Very High Very High
ischemia 663 96.88 Very High Very High Very High
psoriasis 37 95.60 Very High Very High Very High
rheumatoid arthritis 55 90.32 High High
Inflammatory stimuli 37 88.72 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8396 100.00 Very High Very High Very High
Targeted Disruption 3124 100.00 Very High Very High Very High
Sepsis 527 99.92 Very High Very High Very High
Hyperglycemia 306 99.92 Very High Very High Very High
Glioma 111 99.86 Very High Very High Very High
Lung Cancer 259 99.84 Very High Very High Very High
Colon Cancer 37 99.84 Very High Very High Very High
Pulmonary Fibrosis 149 99.78 Very High Very High Very High
Cancer 1188 99.76 Very High Very High Very High
Neuroblastoma 40 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An intriguing finding is that, contrary to many systems designed to maintain homeostasis, RAGE expression is increased in inflammatory states when it binds to its ligands [21,22].
Gene_expression (expression) of RAGE associated with inflammation
1) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.88 Pain Relevance 0.12
The expression of RAGE protein was examined by Western immunoblot analysis of lung tissue where RAGE is constitutively expressed at high levels.
Gene_expression (expression) of RAGE protein in lung
2) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.08 Pain Relevance 0
In contrast to the expression of RAGE in RAGE +/+ mice, no RAGE protein was detected in the lungs of RAGE-/- mice.
Gene_expression (detected) of RAGE protein in lungs
3) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.08 Pain Relevance 0
Immunohistochemistry using anti-RAGE IgG and anti-CD31 IgG showed that RAGE was expressed in endothelial cells in the diabetic heart (Fig. 1I and J, respectively).
Gene_expression (expressed) of RAGE in heart associated with diabetes mellitus
4) Confidence 0.70 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.01 Pain Relevance 0
Immunohistochemistry using anti-RAGE IgG and antiĀ–Mac-3 IgG demonstrated that RAGE was expressed in mononuclear phagocytes in the diabetic heart (Fig. 1K and L, respectively).
Gene_expression (expressed) of RAGE in heart associated with diabetes mellitus
5) Confidence 0.70 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.98 Pain Relevance 0
Together, these studies indicated that RAGE expression was increased in the type 1 diabetic heart, particularly in endothelial cells and mononuclear phagocytes.
Gene_expression (expression) of RAGE in mononuclear phagocytes associated with diabetes mellitus
6) Confidence 0.70 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.00 Pain Relevance 0
Immunostaining with anti-RAGE IgG revealed that RAGE expression in the Tg mouse heart was localized to endothelial cells and not to cardiomyocytes (Fig. 6A).
Gene_expression (expression) of RAGE in heart associated with targeted disruption
7) Confidence 0.70 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.57 Pain Relevance 0.04
In addition to AGEs, although expression of RAGE ligand S100/calgranulin (12) was not demonstrated in the hearts of nondiabetic BB/W rats (Fig. 1C), S100/calgranulin epitopes were evident in diabetic BB/W rat heart (Fig. 1D), in both vascular cells and cardiomyocytes.
Gene_expression (expression) of RAGE in hearts associated with diabetes mellitus
8) Confidence 0.70 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.93 Pain Relevance 0
RAGE expression is highly detrimental to animals challenged systemically with L. monocytogenes as evidenced by the marked survival benefits observed in homozygous RAGE knockouts and heterozygotes compared with wild-type animals.
Gene_expression (expression) of RAGE
9) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.41 Pain Relevance 0.04
The expression of RAGE protein was examined by Western immunoblot analysis of lung tissue where RAGE is constitutively expressed at high levels.
Gene_expression (expressed) of RAGE in lung
10) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.08 Pain Relevance 0
In contrast to the expression of RAGE in RAGE +/+ mice, no RAGE protein was detected in the lungs of RAGE-/- mice.
Gene_expression (expression) of RAGE in lungs
11) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.08 Pain Relevance 0
In this study, the administration of anti-RAGE mAb and a genetic deletion of RAGE conferred resistance to the lethal effects of CLP.
Gene_expression (deletion) of RAGE
12) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.62 Pain Relevance 0.03
The IgG2b anti-murine RAGE mAb was developed by Wyeth (Cambridge, MA, USA).
Gene_expression (anti) of RAGE mAb
13) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.51 Pain Relevance 0
To dissect the role of RAGE signaling in endothelial cell in the diabetic heart, we generated Tg mice in which DN RAGE expression was directed to endothelial cells by the PPET (20).
Gene_expression (expression) of RAGE in endothelial cells associated with targeted disruption and diabetes mellitus
14) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.61 Pain Relevance 0.04
Targeted expression of DN RAGE in endothelial cells or mononuclear phagocytes attenuated CML accumulation in these diabetic hearts under all perfusion conditions, whereas pentosidine was attenuated in diabetic Tg DN MSR RAGE after I/R and furosine was attenuated in diabetic Tg DN PEET RAGE hearts after I/R.
Gene_expression (expression) of RAGE in mononuclear phagocytes associated with targeted disruption, myeloid leukemia and diabetes mellitus
15) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.88 Pain Relevance 0
Tg mice expressing DN RAGE in endothelial cells.
Gene_expression (expressing) of RAGE in endothelial cells associated with targeted disruption
16) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.51 Pain Relevance 0.03
Tg mice expressing DN RAGE in cells of mononuclear phagocyte lineage.
Gene_expression (expressing) of RAGE in mononuclear phagocyte associated with targeted disruption
17) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.82 Pain Relevance 0.06
First, it is plausible that distinct cell types expressing basal levels of RAGE, such as cardiomyocytes or T lymphocytes, may contribute to the findings on functional recovery observed in RAGE-KO mice.
Gene_expression (expressing) of RAGE in T lymphocytes
18) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.92 Pain Relevance 0.04
DN RAGE was selectively expressed in mononuclear phagocyte, and there was no evidence that transgene expression was extended outside of monocytes/macrophages (22).
Gene_expression (expressed) of RAGE in macrophages
19) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.76 Pain Relevance 0.04
Ischemic insult induces increases in AGE-RAGE expression and leads to increased injury (45).
Gene_expression (expression) of AGE-RAGE associated with injury
20) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.41 Pain Relevance 0.03

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