INT224369

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 40.57
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
hearts 5
endothelial cells 1
neurons 1
tail 1
nucleus 1
Ager (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1549 99.84 Very High Very High Very High
Abeta 312 99.84 Very High Very High Very High
psoriasis 26 99.04 Very High Very High Very High
Inflammatory response 84 98.68 Very High Very High Very High
cytokine 391 92.48 High High
rheumatoid arthritis 33 91.80 High High
Arthritis 52 88.68 High High
Osteoarthritis 52 87.96 High High
ischemia 134 85.20 High High
fibrosis 104 84.56 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1794 100.00 Very High Very High Very High
Targeted Disruption 670 100.00 Very High Very High Very High
Injury 381 100.00 Very High Very High Very High
Prostate Cancer 26 99.86 Very High Very High Very High
INFLAMMATION 1659 99.84 Very High Very High Very High
Myocardial Infarction 46 99.84 Very High Very High Very High
Stress 433 99.76 Very High Very High Very High
Skin Cancer 26 99.56 Very High Very High Very High
Hypersensitivity 85 99.28 Very High Very High Very High
Disease 396 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specificity of the antibody was demonstrated by binding to RAGE on the cell surface, direct binding to sRAGE, and immunohistochemistry (manuscript in preparation).
RAGE Binding (binding) of
1) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.53 Pain Relevance 0
RAGE is a pattern-recognition receptor that binds diverse classes of endogenous molecules.
RAGE Binding (binds) of
2) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 1.17 Pain Relevance 0.20
Specificity of the antibody was demonstrated by binding to RAGE on the cell surface, direct binding to sRAGE, and immunohistochemistry (manuscript in preparation).
sRAGE Binding (binding) of
3) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.53 Pain Relevance 0
A major way in which AGEs exert their cellular effects is by ligation of the multiligand receptor for AGE (RAGE) (10–13).
RAGE Binding (ligation) of
4) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.09 Pain Relevance 0.16
Equivalent amounts of total protein from each sample were analyzed by electrophoresis on a NuPAGE 4% to 12% Bis-Tris gel (Invitrogen Corporation, Carlsbad, CA, USA) and detected with immunodetection with the RAGE mAb or actin antibody and a horseradish peroxidase-conjugated anti-donkey antibody using standard protocols.
RAGE mAb Binding (immunodetection) of
5) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.25 Pain Relevance 0
This mAb is a high-affinity rat-derived anti-mouse RAGE antibody with a binding affinity of 0.3 nM for murine dimeric RAGE and binds to the N-terminal region of RAGE.
RAGE Binding (binds) of
6) Confidence 0.32 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.58 Pain Relevance 0
Specificity of the antibody was demonstrated by binding to RAGE on the cell surface, direct binding to sRAGE, and immunohistochemistry (manuscript in preparation).
RAGE Binding (binding) of
7) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.54 Pain Relevance 0
This mAb is a high-affinity rat-derived anti-mouse RAGE antibody with a binding affinity of 0.3 nM for murine dimeric RAGE and binds to the N-terminal region of RAGE.
RAGE Binding (binds) of
8) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.59 Pain Relevance 0
Immunostaining with anti-RAGE IgG revealed that RAGE expression in the Tg mouse heart was localized to endothelial cells and not to cardiomyocytes (Fig. 6A).
anti-RAGE Binding (Immunostaining) of in heart associated with targeted disruption
9) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.63 Pain Relevance 0.04
In conclusion, these studies definitively link RAGE to myocardial ischemic injury and dysfunction in the diabetic heart.
RAGE Binding (link) of in heart associated with diabetes mellitus and myocardial infarction
10) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.96 Pain Relevance 0
Interestingly, after I/R, CML levels were significantly greater in diabetic WT hearts in comparison with diabetic RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts (Table 2).
RAGE-KO Binding (comparison) of in hearts associated with targeted disruption, myeloid leukemia and diabetes mellitus
11) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 3.35 Pain Relevance 0
Interestingly, after I/R, CML levels were significantly greater in diabetic WT hearts in comparison with diabetic RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts (Table 2).
RAGE Binding (comparison) of in hearts associated with targeted disruption, myeloid leukemia and diabetes mellitus
12) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 3.42 Pain Relevance 0
We observed that in diabetic RAGE KO, Tg DN PPET RAGE, and Tg DN MSR RAGE mice hearts, protection from injury due to I/R was also associated with reductions in caspase-3 activation and cytochrome c release.
RAGE Binding (associated) of in hearts associated with targeted disruption, diabetes mellitus and injury
13) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.26 Pain Relevance 0
Transgenic (Tg) DN MSR RAGE and Tg DN PPET RAGE mice were prepared and characterized as previously described (20,22).
RAGE Binding (characterized) of associated with targeted disruption
14) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.67 Pain Relevance 0
We extended our studies to murine models, wherein genetic modification of RAGE would complement pharmacological blockade of ligand-RAGE interaction (sRAGE).
sRAGE Binding (interaction) of
15) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.34 Pain Relevance 0
We extended our studies to murine models, wherein genetic modification of RAGE would complement pharmacological blockade of ligand-RAGE interaction (sRAGE).
RAGE Binding (interaction) of
16) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.34 Pain Relevance 0
The binding of RAGE by AGEs is capable of mediating inflammatory responses and oxidative stress and leads to diabetic vascular complications [136, 137].
RAGE Binding (binding) of associated with diabetic angiopathy, stress and inflammatory response
17) Confidence 0.13 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.14 Pain Relevance 0.07
AGE products bind to RAGE, which is present in neurons and binds to amyloidogenic APP derivative A?
RAGE Binding (binds) of in neurons
18) Confidence 0.09 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.21 Pain Relevance 0.12
It binds to the RAGE C1 and C2 domains instead of the V domain [49].
RAGE C1 Binding (binds) of
19) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.03 Pain Relevance 0.17
It can also bind to RAGE expressed on endothelial cells, signaling through the NF-?
RAGE Binding (bind) of in endothelial cells
20) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.97 Pain Relevance 0.17

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