INT224396

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.57
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UROD) small molecule metabolic process (UROD) lyase activity (UROD)
nucleolus (UROD) nucleus (UROD) cytoplasm (UROD)
Anatomy Link Frequency
liver 1
respiratory 1
UROD (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 98.96 Very High Very High Very High
cva 3 81.72 Quite High
Inflammation 5 19.44 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 28 97.04 Very High Very High Very High
Respiratory Distress 9 93.84 High High
Infection 101 92.40 High High
Pneumothorax 3 82.28 Quite High
Cv General 3 Under Development 3 81.72 Quite High
Asphyxia 3 80.72 Quite High
Sepsis 80 64.32 Quite High
Disease 3 55.44 Quite High
INFLAMMATION 6 19.44 Low Low
Death 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the group of patients undergoing liver resection, the median PCT on the first postoperative day was 0.6 ng/mL (minimum 0.1 ng/mL, maximum 2.5 ng/mL) and PCT levels peaked on the second postoperative day (median 1.1 ng/mL, minimum 0.3 ng/mL, maximum 3.6 ng/mL) and then decreased to the normal range (Figure 1).
Negative_regulation (decreased) of PCT in liver
1) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0 Pain Relevance 0
Third, prepartum and intrapartum administration of antibiotics may affect PCT concentrations in the umbilical cord [30], and postnatal administration of antibiotics will decrease PCT concentrations more rapidly than CRP concentrations [31,32].
Negative_regulation (decrease) of PCT
2) Confidence 0.14 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC3016366 Disease Relevance 0.63 Pain Relevance 0.04
To provide a margin of safety, the maximal normal value of PCT is defined as 10 ng/ml (18-36 hours of life) which, according to the literature is about 50% of the highest PCT concentrations measured in neonates with respiratory distress not related to infection [33].
Negative_regulation (value) of PCT in respiratory associated with respiratory distress and infection
3) Confidence 0.10 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC3016366 Disease Relevance 0.35 Pain Relevance 0
Firstly, the level of elevation in PCT was much higher in septic neonates versus healthy newborns and secondly, the absence of a decrease of PCT values after the initial cytokine release post-partum is indicative of a bacterial infection.
Negative_regulation (decrease) of PCT associated with bacterial infection and cytokine
4) Confidence 0.10 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC3016366 Disease Relevance 0.59 Pain Relevance 0.08

General Comments

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