INT2244

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.28
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
gum 6
esophageal sphincter 2
glands 2
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 92.48 High High
Paracetamol 3 87.96 High High
depression 3 81.08 Quite High
Central nervous system 1 78.84 Quite High
algil 2 77.56 Quite High
Inflammation 1 70.60 Quite High
Bile 1 60.84 Quite High
qutenza 6 50.00 Quite Low
Somatostatin 3 18.56 Low Low
nud 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 30 99.90 Very High Very High Very High
Gastrinoma 17 99.68 Very High Very High Very High
Disease 14 98.92 Very High Very High Very High
Ulcers 9 98.74 Very High Very High Very High
Pancreatitis 3 98.40 Very High Very High Very High
Gastroesophageal Reflux Disease 50 98.10 Very High Very High Very High
Hypertension 1 97.84 Very High Very High Very High
Fatigue 1 95.20 Very High Very High Very High
Pain 6 92.48 High High
Vomiting 9 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIM: To identify VR1-expressing endocrine-like cells in human antral glands and to examine whether stimulation with capsaicin causes release of gastrin, somatostatin, and serotonin.
Spec (whether) Positive_regulation (causes) of Localization (release) of gastrin in glands
1) Confidence 0.68 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
The secretory studies showed an increase in release of gastrin and somatostatin compared to the control vials (P = 0.003; P = 0.013).
Positive_regulation (increase) of Localization (release) of gastrin
2) Confidence 0.68 Published 2009 Journal Dig. Dis. Sci. Section Body Doc Link 18668366 Disease Relevance 0 Pain Relevance 0
After 4--6 weeks of a full dose cimetidine regimen, both basal and pentagastrin stimulated gastric acid secretion were reduced and peptone meal stimulated serum gastrin increased; the basal gastrinaemia remained unchanged.
Positive_regulation (stimulated) of Localization (secretion) of gastrin
3) Confidence 0.45 Published 1979 Journal Acta Hepatogastroenterol (Stuttg) Section Abstract Doc Link 386698 Disease Relevance 0.33 Pain Relevance 0.09
However, others concluded that the esophagoprotective activity of melatonin against GERD might be related to the inhibitory effect of this indole on gastric acid secretion and due to stimulation of gastrin release, which might attenuate the gastro-esophageal reflux by stimulation of the contractile activity of the lower esophageal sphincter [29].
Positive_regulation (stimulation) of Localization (release) of gastrin in esophageal sphincter associated with gastroesophageal reflux disease
4) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.31 Pain Relevance 0.04
Postprandial GIP secretion was also reduced by addition of guar gum to the protein meal, but protein-stimulated gastrin secretion was enhanced by guar gum.
Positive_regulation (stimulated) of Localization (secretion) of gastrin in gum
5) Confidence 0.33 Published 1985 Journal Br. J. Nutr. Section Abstract Doc Link 4063284 Disease Relevance 0 Pain Relevance 0.09
The observed augmentation of gastrin secretion by guar gum following a protein meal could be due either to the buffering capacity of guar gum or to the attenuation of GIP secretion.
Positive_regulation (due) of Localization (secretion) of gastrin in gum
6) Confidence 0.33 Published 1985 Journal Br. J. Nutr. Section Abstract Doc Link 4063284 Disease Relevance 0 Pain Relevance 0.07
Postprandial GIP secretion was also reduced by addition of guar gum to the protein meal, but protein-stimulated gastrin secretion was enhanced by guar gum.
Positive_regulation (enhanced) of Localization (secretion) of gastrin in gum
7) Confidence 0.22 Published 1985 Journal Br. J. Nutr. Section Abstract Doc Link 4063284 Disease Relevance 0 Pain Relevance 0.09
In addition, hypercalcemia has been associated with acute pancreatitis and peptic ulcer diseases that could be explained by the hypercalcemia-induced activation of trypsin and gastrin secretions, respectively [5].
Positive_regulation (activation) of Localization (secretions) of gastrin associated with ulcers, pancreatitis, hypercalcemia and disease
8) Confidence 0.18 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2596162 Disease Relevance 2.03 Pain Relevance 0.28
Moreover, hypercalcaemia may increase the secretion of gastrin from a gastrinoma.
Spec (may) Positive_regulation (increase) of Localization (secretion) of gastrin associated with gastrinoma and hypercalcemia
9) Confidence 0.12 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 2.61 Pain Relevance 0.08

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