INT224410

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 3
Speculated 2
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 10.46
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
CRP (Homo sapiens)
CIMT (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 182 99.60 Very High Very High Very High
Inflammation 99 98.46 Very High Very High Very High
Angina 85 30.20 Quite Low
Inflammatory marker 2 13.72 Low Low
cva 6 11.68 Low Low
tolerance 17 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
visual analogue scale 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 129 100.00 Very High Very High Very High
Rheumatoid Arthritis 184 99.60 Very High Very High Very High
INFLAMMATION 103 98.46 Very High Very High Very High
Atherosclerosis 453 98.32 Very High Very High Very High
Metabolic Syndrome 102 98.08 Very High Very High Very High
Disease 71 95.76 Very High Very High Very High
Coronary Artery Disease 272 90.28 High High
Disorder Of Lipid Metabolism 70 89.76 High High
Diabetes Mellitus 104 87.28 High High
Dyslipidemia /

Combined Dyslipidemia

17 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRP, assessed both at mean age 49 and at mean age 61, was associated both with CIMT in age and sex adjusted standard regression analyses and with potential confounding factors.
CRP Spec (analyses) Binding (associated) of CIMT
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.38 Pain Relevance 0.03
However, the association of CRP with CIMT attenuated to the null with adjustment for confounding factors in both prospective and cross-sectional analyses.
CRP Binding (association) of CIMT
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.35 Pain Relevance 0.03
In conclusion, the consistency of evidence from both the Mendelian randomisation approach and the multivariable regression analysis approach (each of which has distinct, but differing potential limitations) implies that the association of CRP with CIMT may be better explained by CRP marking the presence of atheroma, or other risk factors rather than having a direct causal role itself, as has been suggested [52].
CRP Binding (association) of CIMT associated with atherosclerosis
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.74 Pain Relevance 0.03
Thus, 4 haplotypes of SNPs +1444, +2302 and +4899 (CAT, CGG, CGT and TGT) remained in the analysis in which genetic variants were used to determine the association of CRP with CIMT.


CRP Binding (association) of CIMT
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.11 Pain Relevance 0
Our study demonstrates significant associations between the cIMT, smoking and CRP in early RA patients, supporting the concept that smoking is associated with more severe inflammation at disease presentation.
CRP Binding (associations) of cIMT associated with nicotine addiction, inflammation, rheumatoid arthritis and disease
5) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 2.30 Pain Relevance 0.51
The role of inflammatory activity became clearer upon multivariate analysis, which revealed a strong association between the cIMT, age and CRP level at presentation (Table 3, adjusted R2 = 0.64).


CRP Binding (association) of cIMT associated with inflammation
6) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.43 Pain Relevance 0.52
The second step of the instrumental variables analysis, consistent with the confounder adjusted standard regression analysis, suggested no association between CRP and CIMT, though this was estimated with wide confidence intervals (table 5).
CRP Neg (no) Binding (association) of CIMT
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.38 Pain Relevance 0
The association between serum CRP and CIMT attenuated towards the null in adjustments for obesity and other risk factors and this is consistent with several previous studies [7]–[9], [47].
CRP Binding (association) of CIMT associated with metabolic syndrome
8) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.57 Pain Relevance 0.04
This null finding is assumed to represent a non-confounded and unbiased estimate of the association between CRP and CIMT because the existence of early stages of atherosclerosis cannot alter inherited haplotypes [15], and the potential confounders of the CRP-atherosclerosis association (e.g., obesity, smoking, physical inactivity or socioeconomic adversity) were distributed evenly among the different CRP haplotypes.
CRP Binding (association) of CIMT associated with nicotine addiction, atherosclerosis and metabolic syndrome
9) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.48 Pain Relevance 0
However, further adjustment for risk factors attenuated these associations to the null suggesting that risk factors may confound or mediate the association between CRP and CIMT.
CRP Binding (association) of CIMT
10) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.35 Pain Relevance 0
Of the separate risk factors, adjustment for BMI alone reduced the age- and sex-adjusted association between CRP and CIMT by 57% (p for association?
CRP Binding (association) of CIMT
11) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.41 Pain Relevance 0
An instrumental variables analysis using CRP genotypes or haplotypes as a proxy for CRP would inform whether CRP levels are causally associated with CIMT [16].
CRP Binding (associated) of CIMT
12) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.32 Pain Relevance 0
For these reasons, it seems unlikely that population stratification would have masked a causal association between CRP and CIMT.
CRP Binding (association) of CIMT
13) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0 Pain Relevance 0
The 4 major haplotypes from the SNPs were consistently associated with CRP level, but not with other risk factors that might confound the association between CRP and CIMT.
CRP Spec (might) Binding (association) of CIMT
14) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.38 Pain Relevance 0.03
The total reduction of the magnitude of the CRP-CIMT association between the two models at the mean age of 61.0 was 75%.
CRP Binding (association) of CIMT
15) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.44 Pain Relevance 0
After adjustment for age and sex, higher contemporaneous and previous serum CRP concentrations were associated with increased CIMT (table 4).
CRP Binding (associated) of CIMT
16) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.37 Pain Relevance 0
When examined using genetic variants as the instrument for serum CRP, there was no inferred association between CRP and CIMT.


CRP Neg (no) Binding (association) of CIMT
17) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.26 Pain Relevance 0
The total reduction of the magnitude of the CRP-CIMT association between the two models at the mean age of 61.0 was 75%.
CRP Binding (association) of CIMT
18) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.44 Pain Relevance 0
The Cardiovascular Risk Factors in Young Finns study used variation in the CRP haplotypes as an instrument for unconfounded CRP levels and found no association between the CRP instrument and CIMT in young adults aged 24 to 39 years [22].
CRP Neg (no) Binding (association) of CIMT
19) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.36 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox