INT224413

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 23.61
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
plaque 3
heart 1
CIMT (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 550 99.84 Very High Very High Very High
Inflammation 201 98.22 Very High Very High Very High
Biofeedback 27 97.92 Very High Very High Very High
anesthesia 3 83.84 Quite High
imagery 44 83.16 Quite High
tolerance 45 72.40 Quite High
Inflammatory marker 6 70.28 Quite High
cva 18 58.40 Quite High
cINOD 6 8.88 Low Low
cytokine 5 7.72 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 219 99.88 Very High Very High Very High
Rheumatoid Arthritis 556 99.84 Very High Very High Very High
Coronary Artery Disease 153 99.80 Very High Very High Very High
Insulin Resistance 114 99.70 Very High Very High Very High
Hypertension 55 99.68 Very High Very High Very High
Atherosclerosis 513 99.52 Very High Very High Very High
Disease 249 99.32 Very High Very High Very High
Hemiplegia 33 99.24 Very High Very High Very High
Atherosclerotic Plaque 21 98.88 Very High Very High Very High
Pressure And Volume Under Development 14 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current data identify the same set of variables – age, smoking, blood pressure and indices of disease activity – to be associated with increased cIMT in early RA as are associated with CV mortality.
Positive_regulation (increased) of cIMT in blood associated with nicotine addiction, rheumatoid arthritis and disease
1) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.83 Pain Relevance 0.52
This indicates that while age is a strong risk factor for increased cIMT, it is not enough to explain the increased incidence of subclinical atherosclerosis in RA patients.
Positive_regulation (increased) of cIMT associated with atherosclerosis and rheumatoid arthritis
2) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.52 Pain Relevance 0.49
These data indicate that patients presenting with early RA have increased atherosclerotic burden as evidenced by increased cIMT and carotid arterial plaque, compared with matched control subjects.


Positive_regulation (increased) of cIMT in plaque associated with atherosclerosis and rheumatoid arthritis
3) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.23 Pain Relevance 0.25
Given the clear association of inflammation with accelerated atherogenesis and CV clinical outcomes in RA, we hypothesized that the cIMT would be increased in RA patients even at an early stage of RA, related to inflammatory factors associated with RA.
Positive_regulation (increased) of cIMT associated with inflammation, atherosclerosis and rheumatoid arthritis
4) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 2.51 Pain Relevance 0.72
It has been argued that systemic inflammation (of which CRP is a marker) might cause increases in blood pressure, BMI and changes in lipid profiles that might mediate an increase in CIMT and CHD risk [48].
Positive_regulation (increase) of CIMT in blood associated with pressure and volume under development, coronary artery disease and inflammation
5) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.75 Pain Relevance 0.05
Our data are the first to show an increased cIMT and increased plaque, and thus show accelerated atherosclerosis in patients at first presentation with symptoms of RA.
Positive_regulation (increased) of cIMT in plaque associated with atherosclerosis and rheumatoid arthritis
6) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.05 Pain Relevance 0.25
While several studies have demonstrated subclinical atherosclerosis in established RA patients, either by increased cIMT or the presence of carotid atherosclerotic plaque [8-14], no study has examined the cIMT or plaque in early RA.
Positive_regulation (increased) of cIMT in plaque associated with atherosclerotic plaque, atherosclerosis and rheumatoid arthritis
7) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 2.00 Pain Relevance 0.43
A Cochrane review concluded that there was emerging evidence supporting CIMT for children with hemiplegia[22].
Positive_regulation (supporting) of CIMT associated with hemiplegia
8) Confidence 0.39 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2832893 Disease Relevance 0.27 Pain Relevance 0
It was associated with cardiovascular risk factors, including hypertension, diabetes, and increased CIMT and independent predictors of multi-vessel disease in patients with coronary atherosclerosis.
Positive_regulation (increased) of CIMT associated with coronary artery disease, diabetes mellitus, hypertension and disease
9) Confidence 0.37 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771847 Disease Relevance 1.07 Pain Relevance 0
Although the two groups were similar in all other clinical characteristics, we cannot be sure that the mean CIMT and FMD were actually the same in both groups prior to treatment.
Positive_regulation (mean) of CIMT
10) Confidence 0.32 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.12 Pain Relevance 0
After adjustment for age and sex, higher contemporaneous and previous serum CRP concentrations were associated with increased CIMT (table 4).
Positive_regulation (increased) of CIMT
11) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.36 Pain Relevance 0
Several observational studies show high circulating CRP to be associated with increased risk of coronary heart disease (CHD) events [4]–[6] and increased carotid intima-media thickness (CIMT) [7]–[9], a subclinical marker of atherosclerosis [10], [11].
Positive_regulation (increased) of CIMT in heart associated with coronary artery disease and atherosclerosis
12) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.83 Pain Relevance 0.04
As an illustration of how CIMT might be augmented
Positive_regulation (augmented) of CIMT
13) Confidence 0.16 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2266825 Disease Relevance 0.07 Pain Relevance 0.13
This may explain to a large extent the different outcomes of ASAP and ENHANCE because changes in response to therapy are correlated with baseline values of LDL-C and CIMT (greater changes in CIMT occur with higher baseline values).39 The failure in ENHANCE to reduce CIMT in FH patients with the same mean age and same dose of the same drug as ASAP may therefore be due to higher baseline CIMT in ASAP.
Positive_regulation (baseline) of CIMT associated with hyperlipoproteinemia type ii
14) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.38 Pain Relevance 0
This may explain to a large extent the different outcomes of ASAP and ENHANCE because changes in response to therapy are correlated with baseline values of LDL-C and CIMT (greater changes in CIMT occur with higher baseline values).39 The failure in ENHANCE to reduce CIMT in FH patients with the same mean age and same dose of the same drug as ASAP may therefore be due to higher baseline CIMT in ASAP.
Positive_regulation (changes) of CIMT associated with hyperlipoproteinemia type ii
15) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.36 Pain Relevance 0
In our study, the mean and maximum values of right and overall CIMT were significantly increased in H. pylori positive subjects compared with negative subjects.
Positive_regulation (increased) of CIMT
16) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 0.82 Pain Relevance 0
Baseline levels of CIMT in SANDS trial were increased (mean, 0.9 mm).


Positive_regulation (increased) of CIMT
17) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.73 Pain Relevance 0.07
In ENHANCE, patients were required to have LDL-C > 5.4 mmol/L (210 mg/dL) after washout of prior therapy, without minimal requirement for CIMT levels.
Neg (without) Positive_regulation (requirement) of CIMT
18) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.24 Pain Relevance 0
There is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects.
Positive_regulation (increase) of CIMT
19) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2936361 Disease Relevance 0.67 Pain Relevance 0
The mean and maximum values of right CIMT were significantly increased in H. pylori positive subjects compared with negative subjects (p < 0.05).
Positive_regulation (increased) of CIMT
20) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 0.79 Pain Relevance 0

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