INT224420

Context Info Confidence 0.13 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.39 Pain Relevance 0.60

extracellular matrix organization (NFKB2, TNFRSF11B) signal transduction (NFKB2, TNFRSF11B) nucleoplasm (NFKB2) DNA binding (NFKB2) cytoplasm (NFKB2) cytosol (NFKB2)

Anatomy Link Frequency osteoblasts 4 NFKB2 (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 132 98.20 cytokine 8 5.00 Inflammation 8 5.00 Pain 4 5.00 Paracetamol 2 5.00 cINOD 2 5.00 Arthritis 2 5.00 Bioavailability 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 132 98.20 Osteoporosis 32 93.36 Hypercalcemia 14 5.00 Disease 12 5.00 INFLAMMATION 10 5.00 Pain 4 5.00 Arthritis 2 5.00 Apoptosis 2 5.00 Death 2 5.00 Necrosis 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we explored in human OA subchondral bone whether chondroitin sulfate (CS), glucosamine sulfate (GS), or both together affect the major bone biomarkers, osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), and the pro-resorptive activity of OA osteoblasts.

Regulation (affect) of nuclear factor-kappa B Binding (ligand) of OPG in osteoblasts associated with osteoarthritis

1) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.69 Pain Relevance 0.30

In the present study, we explored in human OA subchondral bone whether chondroitin sulfate (CS), glucosamine sulfate (GS), or both together affect the major bone biomarkers, osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), and the pro-resorptive activity of OA osteoblasts.

Regulation (affect) of nuclear factor-kappa B Binding (ligand) of osteoprotegerin in osteoblasts associated with osteoarthritis

2) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.69 Pain Relevance 0.30

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