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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11B, TNFRSF11A) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B)
extracellular matrix organization (TNFRSF11B) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
osteoclasts 2
TNFRSF11B (Homo sapiens)
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 97.36 Very High Very High Very High
Osteoarthritis 67 90.64 High High
Inflammation 10 69.36 Quite High
cva 11 27.12 Quite Low
Pain 4 8.12 Low Low
Snapping jaw 8 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Osteoporosis 97 96.56 Very High Very High Very High
Hypercalcemia 31 93.84 High High
Apoptosis 3 93.20 High High
Osteoarthritis 67 90.64 High High
Disorders Of Creatine Metabolism 2 84.08 Quite High
Renal Failure 1 82.76 Quite High
Alopecia 1 76.80 Quite High
Disease 7 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, OPG is considered a decoy receptor that blocks the binding of RANKL to the RANK receptor, located on osteoclast precursors, thereby inhibiting the terminal stage of osteoclastic differentiation and suppressing its activation as well as inducing the apoptosis of mature osteoclasts.
OPG Binding (binding) of RANK in osteoclast associated with osteoporosis and apoptosis
1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 1.30 Pain Relevance 0.30
B (RANK) ligand (RANKL), are known to induce the differentiation of monocytes/macrophages into osteoclasts; whereas osteoprotegerin (OPG), a soluble decoy receptor for RANKL that competes with RANK for RANKL binding, is known to suppress differentiation [1, 2].
OPG Binding (competes) of RANK in osteoclasts
2) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.16 Pain Relevance 0.08
B (RANK), its ligand RANKL, a member of the tumor necrosis factor (TNF) superfamily, and OPG that acts as a decoy receptor for RANKL.
OPG Binding (member) of RANK associated with necrosis and cancer
3) Confidence 0.04 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.90 Pain Relevance 0

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