INT224423

Context Info Confidence 0.19 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.36 Pain Relevance 0.37

signal transduction (TNFRSF11B, TNFRSF11A) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B) cell-cell signaling (TNFRSF11A)

Anatomy Link Frequency osteoclasts 2 TNFRSF11B (Homo sapiens) TNFRSF11A (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 10 97.36 Osteoarthritis 67 90.64 Inflammation 10 69.36 cva 11 27.12 Pain 4 8.12 Snapping jaw 8 5.00 Bioavailability 3 5.00 Potency 3 5.00 cINOD 2 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Cancer 3 100.00 Necrosis 2 100.00 Osteoporosis 97 96.56 Hypercalcemia 31 93.84 Apoptosis 3 93.20 Osteoarthritis 67 90.64 Disorders Of Creatine Metabolism 2 84.08 Renal Failure 1 82.76 Alopecia 1 76.80 Disease 7 74.96

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Key:

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Anatomy

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On the other hand, OPG is considered a decoy receptor that blocks the binding of RANKL to the RANK receptor, located on osteoclast precursors, thereby inhibiting the terminal stage of osteoclastic differentiation and suppressing its activation as well as inducing the apoptosis of mature osteoclasts.

OPG Binding (binding) of RANK in osteoclast associated with osteoporosis and apoptosis

1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 1.30 Pain Relevance 0.30

B (RANK) ligand (RANKL), are known to induce the differentiation of monocytes/macrophages into osteoclasts; whereas osteoprotegerin (OPG), a soluble decoy receptor for RANKL that competes with RANK for RANKL binding, is known to suppress differentiation [1, 2].

OPG Binding (competes) of RANK in osteoclasts

2) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.16 Pain Relevance 0.08

B (RANK), its ligand RANKL, a member of the tumor necrosis factor (TNF) superfamily, and OPG that acts as a decoy receptor for RANKL.

OPG Binding (member) of RANK associated with necrosis and cancer

3) Confidence 0.04 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.90 Pain Relevance 0

General Comments

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