INT224425

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
chondrocytes 2
osteoclast 2
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 24 91.52 High High
Osteoarthritis 69 50.00 Quite Low
Bioavailability 1 48.00 Quite Low
Hyperalgesia 3 41.72 Quite Low
Pain 8 41.04 Quite Low
cytokine 22 33.52 Quite Low
Inflammation 22 31.32 Quite Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 13 92.88 High High
Temporomandibular Joint Syndrome 24 91.52 High High
Hypercalcemia 13 85.52 High High
Osteoarthritis 69 50.00 Quite Low
Hyperalgesia 3 41.72 Quite Low
Pain 8 41.04 Quite Low
INFLAMMATION 23 31.32 Quite Low
Infection 3 25.48 Quite Low
Osteoporosis 19 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In many previous studies on M-CSF, RANKL, and OPG expression in chondrocytes, the culture periods were brief (24?
Regulation (studies) of Gene_expression (expression) of M-CSF in chondrocytes
1) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.09
showed the same effect for the expression of RANKL, M-CSF, and OPG for any culture period, while the control value changed in the long-term culture.
Regulation (effect) of Gene_expression (expression) of M-CSF
2) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
, RANKL, M-CSF, and OPG gene expression was unaffected by the presence of celecoxib.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of M-CSF
3) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
In this context, explorative experiments were carried out in which we looked at whether CS and GS affected the osteoclast differentiation levels and/or the production of M-CSF.
Spec (whether) Regulation (affected) of Gene_expression (production) of M-CSF in osteoclast
4) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.21 Pain Relevance 0

General Comments

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