INT224427

Context Info Confidence 0.49 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.05 Pain Relevance 0.08

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 1 99.80 Osteoarthritis 66 50.60 cytokine 4 5.00 Inflammation 4 5.00 Pain 2 5.00 Paracetamol 1 5.00 cINOD 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 66 50.60 Osteoporosis 16 33.88 Hypercalcemia 7 17.16 Disease 6 5.00 INFLAMMATION 5 5.00 Pain 2 5.00 Arthritis 1 5.00 Apoptosis 1 5.00 Death 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, one can speculate that extracellular CS may bind the OPG heparin domain, thereby enhancing OPG bioavailability by preventing it from being degraded.

Positive_regulation (enhancing) of OPG Binding (bind) of associated with bioavailability

1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

This test has worked.