INT224429

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 4.35
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoblasts 4
chondrocytes 1
osteoclasts 1
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 44 99.06 Very High Very High Very High
Osteoarthritis 332 98.76 Very High Very High Very High
Snapping jaw 16 89.92 High High
Arthritis 93 77.44 Quite High
psoriasis 21 77.12 Quite High
Bioavailability 11 53.80 Quite High
Hyperalgesia 2 41.72 Quite Low
Pain 15 41.04 Quite Low
Inflammation 52 31.32 Quite Low
rheumatoid arthritis 10 30.64 Quite Low
Disease Link Frequency Relevance Heat
Hypercalcemia 111 99.92 Very High Very High Very High
Osteoarthritis 332 98.76 Very High Very High Very High
Osteoporosis 322 96.68 Very High Very High Very High
Arthropathy 14 91.28 High High
Temporomandibular Joint Syndrome 16 89.92 High High
Seronegative Spondarthritis 78 77.44 Quite High
Psoriasis 22 77.12 Quite High
Hypersensitivity 3 61.84 Quite High
Hip Fractures 30 52.76 Quite High
Postmenopausal Osteoporosis 39 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, it should not be excluded that CS and GS may also act indirectly through the production of other factors that in turn modulate OPG/RANKL and/or resorption activity.
Regulation (modulate) of RANKL
1) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.13 Pain Relevance 0.03
In the present study, we explored in human OA subchondral bone whether chondroitin sulfate (CS), glucosamine sulfate (GS), or both together affect the major bone biomarkers, osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), and the pro-resorptive activity of OA osteoblasts.
Regulation (affect) of RANKL in osteoblasts associated with osteoarthritis
2) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.69 Pain Relevance 0.30
The additive effect of both compounds at inhibiting bone resorptive activity could then be explained by the sum of the effect of CS on the OPG and RANKL and the effect of one or both of these compounds on RANKL-independent mechanisms on osteoclastogenesis.
Regulation (effect) of RANKL-independent
3) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.33 Pain Relevance 0.04
The additive effect of both compounds at inhibiting bone resorptive activity could then be explained by the sum of the effect of CS on the OPG and RANKL and the effect of one or both of these compounds on RANKL-independent mechanisms on osteoclastogenesis.
Regulation (effect) of RANKL
4) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.33 Pain Relevance 0.04
In many previous studies on M-CSF, RANKL, and OPG expression in chondrocytes, the culture periods were brief (24?
Regulation (studies) of RANKL in chondrocytes
5) Confidence 0.34 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.09
Given the important role of RANK, RANKL, and OPG in bone metabolism and immune function, it has been suggested that the RANK/RANKL/OPG system and cytokines may work together to cause bone resorption by regulating the RANKL/OPG ratio [35].
Regulation (regulating) of RANKL associated with hypercalcemia and cytokine
6) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.24 Pain Relevance 0.12
We previously showed that patients with OA can be discriminated into two groups classified according to L- or H-OA osteoblasts based on the level of PGE2 production [12,13] and that L-OA osteoblasts (PGE2 levels of less than 2,000 pg/mg protein) were suggested to favor pro-resorptive activity whereas the H-OA osteoblasts favor bone deposition [11,14] To investigate the effects of the compounds on (among other things) the OPG, RANKL, and pro-resorptive activity levels, we chose to perform this study with the L-OA osteoblast specimens.
Spec (investigate) Regulation (effects) of RANKL in osteoblasts associated with osteoporosis and osteoarthritis
7) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 1.00 Pain Relevance 0.37
Other studies have demonstrated the involvement of the calcium-sensing receptor in the effects of strontium ranelate on osteoblasts, osteoclasts, and OPG/RANKL regulation [126].
Regulation (regulation) of RANKL in osteoclasts
8) Confidence 0.23 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.35 Pain Relevance 0
In addition to these direct effects on osteoblasts and osteoclasts, strontium ranelate also modulates the level of osteoprotegerin (OPG) and RANKL, two molecules strongly involved in the regulation of osteoclastogenesis by osteoblasts.
Regulation (modulates) of RANKL in osteoblasts
9) Confidence 0.23 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.47 Pain Relevance 0
To test this hypothesis, we compared the effect of RANKL + M-CSF with GM-CSF + IL-4 on CD16 surface expression.
Regulation (effect) of RANKL
10) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.29 Pain Relevance 0.15
Other studies have demonstrated the involvement of the calcium-sensing receptor in the effects of strontium ranelate on osteoblasts, osteoclasts, and OPG/RANKL regulation [126].
Regulation (regulation) of RANKL in osteoblasts
11) Confidence 0.08 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.35 Pain Relevance 0

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