INT224432

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 5.83
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, VEGFA) extracellular region (TNF, VEGFA) intracellular (TNF)
extracellular matrix organization (TNF) cytoplasm (VEGFA) signal transduction (TNF)
Anatomy Link Frequency
fibroblasts 7
osteoclast 2
spleen 2
blood 1
TNF (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 290 97.92 Very High Very High Very High
cytokine 80 97.64 Very High Very High Very High
Inflammation 370 97.52 Very High Very High Very High
imagery 100 79.88 Quite High
metalloproteinase 10 78.48 Quite High
Potency 10 76.16 Quite High
rheumatoid arthritis 80 66.76 Quite High
Pain 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
psoriasis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 100 100.00 Very High Very High Very High
Necrosis 80 100.00 Very High Very High Very High
Metastasis 20 99.56 Very High Very High Very High
Arthritis 420 97.92 Very High Very High Very High
Synovitis 40 97.80 Very High Very High Very High
INFLAMMATION 260 97.44 Very High Very High Very High
Targeted Disruption 480 95.00 High High
Infection 20 93.40 High High
Breast Cancer 10 85.12 High High
Adhesions 10 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we demonstrated that TNF and IL-1 upregulate VEGF-C expression in CD11b+ OCPs.
TNF Positive_regulation (upregulate) of Gene_expression (expression) of VEGF
1) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.35 Pain Relevance 0.22
We found that TNF also stimulates VEGF-C expression in NIH3T3 and C2C12 fibroblast cell lines (data not shown), suggesting that fibroblast-like cells in synovium could perhaps be another source of VEGF-C in arthritic pannus.
TNF Positive_regulation (stimulates) of Gene_expression (expression) of VEGF in fibroblast associated with arthritis
2) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.14
To determine whether TNF directly upregulates expression of VEGF-C by OCPs, we cultured WT spleen cells with M-CSF for 3 days to generate OCPs, as we described previously [25].
TNF Spec (whether) Positive_regulation (upregulates) of Gene_expression (expression) of VEGF in spleen
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.93 Pain Relevance 0.23
Tumor necrosis factor stimulates osteoclast precursors to produce VEGF-C
Tumor necrosis factor Positive_regulation (stimulates) of Gene_expression (produce) of VEGF in osteoclast associated with necrosis and cancer
4) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.98 Pain Relevance 0.24
While our studies focused on OCPs, others have shown that TNF and/or IL-1 stimulates VEGF-C expression by human lung fibroblasts, blood vascular endothelial cells, and synovial cells [19,46].
TNF Positive_regulation (stimulates) of Gene_expression (expression) of VEGF in fibroblasts
5) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.14
To validate our microarray findings and provide insight into the mechanism of TNF-induced VEGF-C expression in OCPs, we provide preliminary evidence indicating that this response is mediated by NF-?
TNF Positive_regulation (induced) of Gene_expression (expression) of VEGF
6) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.21
It was speculated that inflammatory cytokines, such as tumor necrosis factor (TNF) or interleukin 1 (IL-1), stimulate these CD11b+ cells to produce VEGF-C because TNF and IL-1 increase VEGF-C expression in human lung fibroblasts and human umbilical vein endothelial cells in vitro [18,19].
TNF Positive_regulation (increase) of Gene_expression (expression) of VEGF in fibroblasts associated with necrosis, inflammation, cancer and cytokine
7) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.73 Pain Relevance 0.23
Nuclear factor-kappa B mediates tumor necrosis factor-induced VEGF-C expression
tumor necrosis factor Positive_regulation (induced) of Gene_expression (expression) of VEGF associated with necrosis and cancer
8) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.37 Pain Relevance 0.07
In summary, TNF induces OCPs to produce VEGF-C through NF-?
TNF Positive_regulation (induces) of Gene_expression (produce) of VEGF
9) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.82 Pain Relevance 0.18
While our studies focused on OCPs, others have shown that TNF and/or IL-1 stimulates VEGF-C expression by human lung fibroblasts, blood vascular endothelial cells, and synovial cells [19,46].
TNF Positive_regulation (stimulates) of in blood Gene_expression (expression) of VEGF in fibroblasts
10) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.14

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