INT224434

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.04
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, VEGFA) extracellular region (TNF, VEGFA) intracellular (TNF)
extracellular matrix organization (TNF) cytoplasm (VEGFA) signal transduction (TNF)
Anatomy Link Frequency
fibroblast 1
TNF (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 30 96.36 Very High Very High Very High
Inflammation 111 84.92 Quite High
Arthritis 87 81.00 Quite High
cytokine 24 79.04 Quite High
rheumatoid arthritis 24 30.00 Quite Low
Potency 3 8.12 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 126 93.24 High High
Cancer 30 93.20 High High
Necrosis 24 92.72 High High
Targeted Disruption 144 91.44 High High
INFLAMMATION 78 84.92 Quite High
Synovitis 12 73.68 Quite High
Breast Cancer 3 63.68 Quite High
Rheumatoid Arthritis 24 30.00 Quite Low
Metastasis 6 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that TNF also stimulates VEGF-C expression in NIH3T3 and C2C12 fibroblast cell lines (data not shown), suggesting that fibroblast-like cells in synovium could perhaps be another source of VEGF-C in arthritic pannus.
TNF Positive_regulation (stimulates) of VEGF in fibroblast associated with arthritis
1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.14
These data support TNF induction of VEGF-C expression by activation of NF-?
TNF Positive_regulation (induction) of VEGF
2) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.74 Pain Relevance 0.04
TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-?
TNF Positive_regulation (stimulated) of VEGF
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.89 Pain Relevance 0.26

General Comments

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