INT224447

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 7.33
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FBXO2) protein modification process (FBXO2) endoplasmic reticulum (FBXO2)
cytoplasm (FBXO2)
Anatomy Link Frequency
fat 3
joints 1
endothelial cells 1
adipose tissue 1
adipocytes 1
FBXO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 85 98.26 Very High Very High Very High
cytokine 58 96.60 Very High Very High Very High
imagery 60 95.48 Very High Very High Very High
Inflammation 262 95.08 Very High Very High Very High
Arthritis 174 94.52 High High
rheumatoid arthritis 48 65.52 Quite High
Potency 6 17.12 Low Low
alcohol 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 321 99.84 Very High Very High Very High
Arthritis 252 99.44 Very High Very High Very High
Weight Loss 85 99.06 Very High Very High Very High
Targeted Disruption 293 98.48 Very High Very High Very High
Impaired Glucose Tolerance 95 98.26 Very High Very High Very High
INFLAMMATION 201 95.08 Very High Very High Very High
Insulin Resistance 115 88.48 High High
Disorder Of Lipid Metabolism 45 80.44 Quite High
Cancer 70 77.44 Quite High
Synovitis 24 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that M-CSF-dependent cells that were derived from joints of TNF-Tg mice expressed much higher levels of VEGF-C compared with those of WT mice (Figure 4c) whereas VEGF-A and VEGF-D levels were similar, suggesting that OCPs/monocytes are the major source of VEGF-C in arthritic joints of TNF-Tg mice.
Gene_expression (source) of OCP in joints associated with targeted disruption and arthritis
1) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.77 Pain Relevance 0.04
To validate our microarray findings and provide insight into the mechanism of TNF-induced VEGF-C expression in OCPs, we provide preliminary evidence indicating that this response is mediated by NF-?
Gene_expression (expression) of OCP
2) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.21
B in TNF-induced VEGF-C expression, we treated WT OCPs with an NF-?
Gene_expression (treated) of OCP
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.55 Pain Relevance 0.03
Here, we demonstrated that TNF and IL-1 upregulate VEGF-C expression in CD11b+ OCPs.
Gene_expression (expression) of OCP
4) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.35 Pain Relevance 0.21
TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-?
Gene_expression (expression) of OCP
5) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.89 Pain Relevance 0.26
Our explanation is that OCPs or other VEGF-C-producing cells may need to migrate to the inflamed joints first and then respond to elevated cytokine levels to produce VEGF-C, which then stimulates formation of lymphatic endothelial cells.
Gene_expression (producing) of OCP in endothelial cells associated with cytokine
6) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.79 Pain Relevance 0.43
Unpaired and paired t tests were used to compare NGT and AGT subjects and the effects of weight loss or rosiglitazone and the comparison of fH and fB gene expression between subcutaneous and omental adipose tissue, respectively.
Gene_expression (expression) of fB gene in adipose tissue associated with weight loss, obesity and tolerance
7) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.51 Pain Relevance 0.13
Again, fB gene expression was significantly higher in omental than subcutaneous fat depot but specifically in cells from the SVC fraction (0.096 ± 0.03 vs. 0.022 ± 0.006 relative units, P = 0.001).
Gene_expression (expression) of fB gene in fat
8) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.85 Pain Relevance 0
No differences between fat depots were found regarding fH and fB gene expression in adipocytes (Fig. 2).


Gene_expression (expression) of fB gene in adipocytes associated with obesity
9) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.70 Pain Relevance 0
In both fat depots, fH gene expression was significantly higher than complement fB gene expression (Fig. 2).
Gene_expression (expression) of fH gene in fat
10) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.76 Pain Relevance 0
In both fat depots, fH gene expression was significantly higher than complement fB gene expression (Fig. 2).
Gene_expression (expression) of fB gene in fat
11) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.75 Pain Relevance 0

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