INT224449

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.72 Pain Relevance 0.24

cytosol (FBXO2) protein modification process (FBXO2) endoplasmic reticulum (FBXO2) cytoplasm (FBXO2)

Anatomy Link Frequency fat 2 FBXO2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 18 87.24 Inflammation 82 86.84 rheumatoid arthritis 16 61.16 Arthritis 58 56.84 imagery 20 50.72 Potency 2 17.12 tolerance 17 5.00 alcohol 2 5.00 Inflammatory mediators 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Obesity 65 89.60 Weight Loss 17 87.84 INFLAMMATION 61 86.84 Cancer 22 77.44 Necrosis 18 74.16 Targeted Disruption 97 72.88 Breast Cancer 2 72.68 Insulin Resistance 23 70.56 Disorder Of Lipid Metabolism 9 62.52 Rheumatoid Arthritis 16 61.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B in TNF-induced VEGF-C expression, we treated WT OCPs with an NF-?

Positive_regulation (treated) of Gene_expression (treated) of OCP

1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.55 Pain Relevance 0.03

To validate our microarray findings and provide insight into the mechanism of TNF-induced VEGF-C expression in OCPs, we provide preliminary evidence indicating that this response is mediated by NF-?

Positive_regulation (induced) of Gene_expression (expression) of OCP

2) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.41 Pain Relevance 0.21

In both fat depots, fH gene expression was significantly higher than complement fB gene expression (Fig. 2).

Positive_regulation (higher) of Gene_expression (expression) of fH gene in fat

3) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.76 Pain Relevance 0

General Comments

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