INT224451

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
fibroblasts 2
Il1 (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 97.48 Very High Very High Very High
Inflammation 74 97.28 Very High Very High Very High
rheumatoid arthritis 16 66.44 Quite High
Arthritis 58 62.12 Quite High
imagery 20 56.00 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 16 97.96 Very High Very High Very High
Cancer 20 97.78 Very High Very High Very High
INFLAMMATION 52 97.28 Very High Very High Very High
Infection 4 93.08 High High
Metastasis 4 83.84 Quite High
Rheumatoid Arthritis 16 66.44 Quite High
Arthritis 84 62.12 Quite High
Targeted Disruption 96 21.96 Low Low
Synovitis 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we demonstrated that TNF and IL-1 upregulate VEGF-C expression in CD11b+ OCPs.
IL-1 Positive_regulation (upregulate) of Gene_expression (expression) of VEGF
1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.35 Pain Relevance 0.22
It was speculated that inflammatory cytokines, such as tumor necrosis factor (TNF) or interleukin 1 (IL-1), stimulate these CD11b+ cells to produce VEGF-C because TNF and IL-1 increase VEGF-C expression in human lung fibroblasts and human umbilical vein endothelial cells in vitro [18,19].
IL-1 Positive_regulation (increase) of Gene_expression (expression) of VEGF in fibroblasts associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.73 Pain Relevance 0.23

General Comments

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