INT224457

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Pdgfa) extracellular region (TNF, Pdgfa) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 96.52 Very High Very High Very High
Arthritis 29 96.00 Very High Very High Very High
metalloproteinase 1 86.00 High High
Potency 1 52.32 Quite High
imagery 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 42 96.52 Very High Very High Very High
Targeted Disruption 48 94.80 High High
Metastasis 2 94.68 High High
Cancer 10 87.12 High High
Necrosis 8 86.64 High High
Adhesions 1 86.40 High High
INFLAMMATION 26 81.24 Quite High
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Synovitis 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since TNF is known to induce PDGF signaling [34], we decided to explore the possibility that VEGF-C has a novel role in inflammatory arthritis similar to its role in metastatic cancer [35,36].


TNF Positive_regulation (induce) of PDGF associated with inflammation, metastasis and arthritis
1) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 1.22 Pain Relevance 0.27

General Comments

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