INT224458

Context Info Confidence 0.34 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.47 Pain Relevance 0.26

signal transduction (TNF, Nfkb1) mitochondrion (Nfkb1) intracellular (TNF) DNA binding (Nfkb1) extracellular matrix organization (TNF) protein complex (Nfkb1)

Anatomy Link Frequency macrophage 2 TNF (Homo sapiens) Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 10 96.36 Arthritis 30 81.00 Inflammation 64 75.00 cytokine 37 41.20 rheumatoid arthritis 9 5.00 chemokine 5 5.00 Kinase C 4 5.00 metalloproteinase 2 5.00 Potency 2 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cancer 34 100.00 Necrosis 9 100.00 Targeted Disruption 48 93.12 Death 17 83.44 Arthritis 43 81.00 Synovitis 4 78.32 Aging 103 75.20 Apoptosis 31 56.56 Infection 25 11.84 Viral Infection 3 10.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-?

TNF Positive_regulation (stimulated) of Gene_expression (expression) of nuclear factor-kappa B

1) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.91 Pain Relevance 0.26

Furthermore, CD28 co-stimulation synergizes with TCR activation and induces IL-2, IL-4, IL-5, tumor necrosis factor (TNF), and granulocyte macrophage colony-stimulating factor production via nuclear factor-kappa B (NF-?

TNF Positive_regulation (induces) of Gene_expression (production) of nuclear factor-kappa B in macrophage associated with necrosis and cancer

2) Confidence 0.05 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.55 Pain Relevance 0

General Comments

This test has worked.