INT224458

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Nfkb1) mitochondrion (Nfkb1) intracellular (TNF)
DNA binding (Nfkb1) extracellular matrix organization (TNF) protein complex (Nfkb1)
Anatomy Link Frequency
macrophage 2
TNF (Homo sapiens)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 96.36 Very High Very High Very High
Arthritis 30 81.00 Quite High
Inflammation 64 75.00 Quite High
cytokine 37 41.20 Quite Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 34 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Targeted Disruption 48 93.12 High High
Death 17 83.44 Quite High
Arthritis 43 81.00 Quite High
Synovitis 4 78.32 Quite High
Aging 103 75.20 Quite High
Apoptosis 31 56.56 Quite High
Infection 25 11.84 Low Low
Viral Infection 3 10.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-?
TNF Positive_regulation (stimulated) of Gene_expression (expression) of nuclear factor-kappa B
1) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246237 Disease Relevance 0.91 Pain Relevance 0.26
Furthermore, CD28 co-stimulation synergizes with TCR activation and induces IL-2, IL-4, IL-5, tumor necrosis factor (TNF), and granulocyte macrophage colony-stimulating factor production via nuclear factor-kappa B (NF-?
TNF Positive_regulation (induces) of Gene_expression (production) of nuclear factor-kappa B in macrophage associated with necrosis and cancer
2) Confidence 0.05 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.55 Pain Relevance 0

General Comments

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