INT224462

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
F2RL1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 24 100.00 Very High Very High Very High
Osteoarthritis 66 87.68 High High
COX2 3 40.16 Quite Low
Inflammation 16 39.12 Quite Low
cytokine 11 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 67 87.68 High High
Necrosis 3 58.16 Quite High
Cancer 4 57.80 Quite High
INFLAMMATION 15 39.12 Quite Low
Disease 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 48 hours of incubation, PAR-2 activation significantly induced MMP-1 and COX-2 starting at 10 ?
Positive_regulation (activation) of PAR-2 Positive_regulation (induced) of MMP-1 associated with metalloproteinase
1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.47 Pain Relevance 0.28

General Comments

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