INT224463

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
mast cell 1
TPSAB1 (Homo sapiens)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 51 97.88 Very High Very High Very High
agonist 30 97.80 Very High Very High Very High
Hyperalgesia 3 78.72 Quite High
Thermal hyperalgesia 1 69.20 Quite High
Osteoarthritis 66 67.88 Quite High
cytokine 14 65.84 Quite High
metalloproteinase 24 51.04 Quite High
rheumatoid arthritis 1 45.20 Quite Low
antagonist 5 45.08 Quite Low
Arthritis 7 37.20 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 97.88 Very High Very High Very High
Cancer 24 89.28 High High
Pathologic Processes 1 87.76 High High
Metastasis 4 86.80 High High
Hyperalgesia 4 78.72 Quite High
Osteoarthritis 67 67.88 Quite High
Nociception 2 67.20 Quite High
Disease 10 64.64 Quite High
Edema 1 63.20 Quite High
Adhesions 2 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
tryptase Positive_regulation (activated) of PAR2 associated with inflammation
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.66 Pain Relevance 0.23
PAR-1, PAR-3, and PAR-4 are activated by thrombin, whereas PAR-2 is activated mainly by trypsin but also by mast cell tryptase.
tryptase Positive_regulation (activated) of PAR-2 in mast cell
2) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.83 Pain Relevance 0.53

General Comments

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