INT22448

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Context Info
Confidence 0.33
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.95
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (GPI) small molecule metabolic process (GPI) carbohydrate metabolic process (GPI)
cytoplasm (GPI) cytosol (GPI) extracellular space (GPI)
Anatomy Link Frequency
thalamus 1
central nervous system 1
neural 1
GPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 126 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
deep brain stimulation 259 99.96 Very High Very High Very High
Central nervous system 1 99.76 Very High Very High Very High
Somatostatin 4 99.08 Very High Very High Very High
Cholecystokinin 3 98.88 Very High Very High Very High
Neuropeptide 5 92.64 High High
Spinal cord 7 82.20 Quite High
anesthesia 1 75.00 Quite High
Enkephalin 1 72.32 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 127 93.88 High High
Disease 385 92.24 High High
Tremor 55 90.24 High High
Hemolytic Anemia 2 89.52 High High
Death 1 83.56 Quite High
Gliosis 1 77.84 Quite High
Dyskinesias 45 68.24 Quite High
Aging 4 63.76 Quite High
Dysphagia 2 59.08 Quite High
Dysarthria 3 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, maintaining the flexibility to perform model-based control the STN, GPi or VIM, depending upon a patient’s symptom complex, is a challenge for future work.
Regulation (control) of GPi
1) Confidence 0.33 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.32 Pain Relevance 0.05
We will now extend our model, from the oscillations between the GPe and the STN (Terman et al. 2002), to the effect of these oscillations on the thalamus through the intermediary way station of the GPi.
Regulation (effect) of GPi in thalamus associated with thalamus
2) Confidence 0.29 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.19 Pain Relevance 0.22
To focus on the possible effects of GPI mutations on the central nervous system through an effect on neuroleukin activity, we analysed DNA isolated from two patients with severe GPI deficiency, one of them with additional neurological deficits, and their families.
Regulation (effect) of neuroleukin in central nervous system associated with central nervous system
3) Confidence 0.27 Published 1998 Journal Hum. Genet. Section Abstract Doc Link 9856489 Disease Relevance 0.16 Pain Relevance 0.12
In Rubin & Terman (2004), such an effect can be shown as a slow on and off square-wave modulation of GPi output.
Regulation (modulation) of GPi
4) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.28 Pain Relevance 0.10
Note two things about the effect of stimulation on the GPi activity in figure 6: (i) the frequency is increased and (ii) the neural response becomes less episodic and more continuous.
Regulation (effect) of GPi in neural
5) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0 Pain Relevance 0.14
In rats, a postmortem delay of up to 8 hours did not affect SP, Met-Enk, PHI, or NPY and decreased SST, CCK, and VIP levels.
Neg (not) Regulation (affect) of PHI associated with somatostatin, cholecystokinin and substance p
6) Confidence 0.09 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.17 Pain Relevance 0.77
The relative safety and efficacy of STN vs GPi DBS, however, has been compared formerly in only small studies (Burchiel et al 1999).
Regulation (efficacy) of GPi associated with deep brain stimulation
7) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.83 Pain Relevance 0.46

General Comments

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