INT224480

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 5.20
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
cartilage 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 208 99.76 Very High Very High Very High
Bioavailability 3 99.44 Very High Very High Very High
Osteoarthritis 198 99.30 Very High Very High Very High
Arthritis 28 98.76 Very High Very High Very High
cytokine 53 97.72 Very High Very High Very High
antagonist 29 95.76 Very High Very High Very High
agonist 142 92.68 High High
COX2 13 87.04 High High
metalloproteinase 72 85.04 High High
fibrosis 4 78.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 237 99.76 Very High Very High Very High
Osteoarthritis 201 99.30 Very High Very High Very High
Cancer 96 98.88 Very High Very High Very High
Arthritis 28 98.76 Very High Very High Very High
Metastasis 16 98.44 Very High Very High Very High
Inflammatory Bowel Disease 4 97.44 Very High Very High Very High
Targeted Disruption 11 96.96 Very High Very High Very High
Necrosis 11 94.00 High High
Chronic Obstructive Pulmonary Disease 8 91.32 High High
Disease 39 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein modulation was investigated in OA cartilage explants treated with a specific PAR-2-activating peptide (PAR-2-AP), SLIGKV-NH2 (1 to 400 ?
PAR-2-AP Binding (specific) of in cartilage associated with osteoarthritis
1) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 1.01 Pain Relevance 0.55
Protein modulation was investigated in OA cartilage explants treated with a specific PAR-2-activating peptide (PAR-2-AP), SLIGKV-NH2 (1 to 400 ?
PAR-2-activating peptide Binding (specific) of in cartilage associated with osteoarthritis
2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 1.01 Pain Relevance 0.54
Our finding of an increased level of PAR-2 induced by TGF-?
PAR-2 Spec (finding) Binding (finding) of
3) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.67 Pain Relevance 0.39
PAR2 is known to couple to Gi, and both ERK and MEK are signal transducers in the Gi signaling cascade.
PAR2 Binding (couple) of
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.29 Pain Relevance 0.04
PAR2 has been associated with cell proliferation in cancer and metastasis [6], [7], [8], [9].
PAR2 Binding (associated) of associated with cancer and metastasis
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.40 Pain Relevance 0
release [34], has only mM affinity for PAR2 and selectivity for this one receptor is extremely unlikely.
PAR2 Binding (affinity) of
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.98 Pain Relevance 0.38
Thus, because of the strong interactions of PAR2 with NF?
PAR2 Binding (interactions) of
7) Confidence 0.30 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.05 Pain Relevance 0
B phosphorylation and in DNA reporter activity [29], whilst other groups have clearly demonstrated PAR2 coupling to NF?
PAR2 Binding (coupling) of
8) Confidence 0.30 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD) and key events in tumor progression (angiogenesis, metastasis), but they have relied heavily on the use of single agonists to identify physiological roles for PAR2.
PAR2 Binding (associated) of associated with inflammatory bowel disease, inflammation, cancer, agonist, metastasis and arthritis
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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