INT224481

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.07
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
chondrocytes 2
cartilage 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 330 99.60 Very High Very High Very High
agonist 85 98.08 Very High Very High Very High
Inflammation 160 98.00 Very High Very High Very High
cytokine 65 97.20 Very High Very High Very High
Arthritis 21 88.76 High High
metalloproteinase 120 85.28 High High
rheumatoid arthritis 5 85.20 High High
COX2 17 79.92 Quite High
Hyperalgesia 15 77.88 Quite High
Thermal hyperalgesia 5 73.20 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 335 99.60 Very High Very High Very High
INFLAMMATION 171 98.00 Very High Very High Very High
Cancer 62 92.88 High High
Targeted Disruption 9 90.84 High High
Arthritis 21 88.76 High High
Rheumatoid Arthritis 5 85.20 High High
Neurogenic Inflammation 5 81.80 Quite High
Breast Cancer 2 80.08 Quite High
Hyperalgesia 20 77.88 Quite High
Thrombosis 2 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have shown that Gq/11 plays a positive role in the regulation of PAR2 mediated NF?
Regulation (regulation) of PAR2
1) Confidence 0.37 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
To explore the mechanism underlying PAR-2 modulation in human OA cartilage, we studied the effects of two proinflammatory cytokines, IL-1?
Regulation (modulation) of PAR-2 in cartilage associated with osteoarthritis and cytokine
2) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.52 Pain Relevance 0.38
We investigated the in situ levels and modulation of PAR-2 in human normal and osteoarthritis (OA) cartilage/chondrocytes.
Spec (investigated) Regulation (modulation) of PAR-2 in cartilage associated with osteoarthritis
3) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.73 Pain Relevance 0.49
This study aimed to investigate the in situ levels and modulation of PAR-2 in human normal and OA cartilage, determine its functional consequences on this tissue, and evaluate the chondrocyte signalling pathways involved in PAR-2 activity.
Spec (investigate) Regulation (modulation) of PAR-2 in chondrocyte associated with osteoarthritis
4) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.33 Pain Relevance 0.75
Regulation of PAR-2 synthesis
Regulation (Regulation) of PAR-2
5) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.52 Pain Relevance 0.35
The significance of this new observation for PAR2 activation in terms of cellular and physiological mechanisms remains to be elucidated, but points to the need for studies that investigate PAR2 regulation in both normal metabolism and metabolic dysfunction.


Spec (investigate) Regulation (regulation) of PAR2
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.85 Pain Relevance 0.19
New PAR2 must therefore be produced in the cell and expressed on the cell surface to account for the observed up-regulation of PAR2 mRNA in response to the two extracellular PAR2 agonists.


Regulation (regulation) of PAR2 associated with agonist
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.40 Pain Relevance 0.09
We investigated the in situ levels and modulation of PAR-2 in human normal and osteoarthritis (OA) cartilage/chondrocytes.
Spec (investigated) Regulation (modulation) of PAR-2 in chondrocytes associated with osteoarthritis
8) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.73 Pain Relevance 0.49

General Comments

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