INT224483

Context Info Confidence 0.15 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.16 Pain Relevance 0.86

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 105 100.00 metalloproteinase 24 100.00 Inflammation 19 100.00 cytokine 15 70.00 agonist 4 22.16 cINOD 4 5.00 COX2 3 5.00 Hyperalgesia 3 5.00 Inflammatory mediators 2 5.00 Analgesic 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 107 100.00 INFLAMMATION 20 100.00 Hypercalcemia 11 59.36 Osteoporosis 6 50.00 Disease 12 5.00 Apoptosis 5 5.00 Cancer 5 5.00 Hyperalgesia 4 5.00 Necrosis 3 5.00 Arthritis 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To determine the functional consequence of PAR-2 activation, we studied some of the major catabolic/inflammatory factors involved in OA pathophysiology, including MMP-1, MMP-13, and COX-2 (Figure 4).

Regulation (some) of Regulation (involved) of MMP-13 associated with inflammation, metalloproteinase and osteoarthritis

1) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.77 Pain Relevance 0.66

These findings also agree with studies on other cell types demonstrating the critical role of ERK1/2 and p38 activation in the regulation of MMP-13 as well as with data showing that rhein reduces the IL-1?

Regulation (role) of Regulation (regulation) of MMP-13

2) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.38 Pain Relevance 0.20

General Comments

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