INT224486

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
chondrocytes 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 100.00 Very High Very High Very High
metalloproteinase 24 94.80 High High
cytokine 11 90.24 High High
Inflammation 16 69.56 Quite High
agonist 4 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 67 100.00 Very High Very High Very High
INFLAMMATION 15 69.56 Quite High
Skin Cancer 17 55.36 Quite High
Cancer 86 50.00 Quite Low
Metastasis 25 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 14 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further validate whether the increased activation of JNK-mediated downregulation of VEGF-C is dependent on podoplanin, the levels of phosphorylated JNK and VEGF-C mRNA were examined using siRNA methods.
Spec (whether) Regulation (dependent) of Phosphorylation (phosphorylated) of JNK
1) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.06 Pain Relevance 0
The effect of PAR-2 activation on the phosphorylated levels of three MAP kinases of the OA chondrocytes (n = 3 to 4), namely Erk1/2, p38, and JNK, and on NF-?
Regulation (effect) of Phosphorylation (phosphorylated) of JNK in chondrocytes associated with osteoarthritis
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.47 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox