INT224489

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
chondrocytes 2
cartilage 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 132 99.84 Very High Very High Very High
Bioavailability 2 89.84 High High
Inflammation 42 80.96 Quite High
metalloproteinase 48 75.92 Quite High
cytokine 26 63.52 Quite High
agonist 21 55.20 Quite High
antagonist 7 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 134 99.84 Very High Very High Very High
INFLAMMATION 42 80.96 Quite High
Apoptosis 1 57.68 Quite High
Disease 12 51.92 Quite High
Cancer 10 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data (n = 3 to 4) revealed that only the p38 inhibitor markedly downregulated (p < 0.06) the PAR-2 production in OA cartilage (Figure 3).
Negative_regulation (downregulated) of Gene_expression (production) of PAR-2 in cartilage associated with osteoarthritis
1) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.83 Pain Relevance 0.58
downregulated PAR-2 levels in OA but increased its levels in normal chondrocytes.
Negative_regulation (downregulated) of Gene_expression (levels) of PAR-2 in chondrocytes associated with osteoarthritis
2) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.62 Pain Relevance 0.39
B [29], the overall outcome of PAR2/TNFR1 is a loss in JNK activation only.
Negative_regulation (loss) of Gene_expression (outcome) of PAR2
3) Confidence 0.35 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.06 Pain Relevance 0

General Comments

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