INT224491

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
chondrocytes 1
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 98.88 Very High Very High Very High
agonist 30 76.32 Quite High
cytokine 14 38.80 Quite Low
Inflammation 51 10.92 Low Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 67 98.88 Very High Very High Very High
Hyperplasia 1 23.20 Low Low
Cancer 24 21.04 Low Low
INFLAMMATION 57 10.92 Low Low
Disease 10 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PAR2 mRNA itself was found to slightly increase upon treatment with trypsin (1.7 fold) or PAR2-AP (1.2 fold) for up to 6 h.
Transcription (Expression) of PAR2
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.11
The levels of PAR-2 mRNA in normal (n = 4) and OA (n = 6) chondrocytes were determined by real-time PCR.
Spec (determined) Transcription (levels) of PAR-2 in chondrocytes associated with osteoarthritis
2) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.31 Pain Relevance 0.15

General Comments

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