INT224494

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.67
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 56 99.54 Very High Very High Very High
Inflammation 71 94.28 High High
Arthritis 9 87.68 High High
antagonist 15 80.52 Quite High
Osteoarthritis 66 78.32 Quite High
Inflammatory mediators 7 74.16 Quite High
metalloproteinase 24 72.48 Quite High
cytokine 22 64.72 Quite High
fibrosis 1 63.56 Quite High
Potency 3 56.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 94.28 High High
Disease 14 90.20 High High
Arthritis 9 87.68 High High
Injury 1 81.04 Quite High
Cancer 28 79.60 Quite High
Osteoarthritis 67 78.32 Quite High
Cirrhosis 1 63.56 Quite High
Asthma 2 62.32 Quite High
Peptic Ulcer 1 61.56 Quite High
Cardiovascular Disease 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our initial studies indicated that DAG-dependent PKC isoforms are involved in the response since PMA was able to mimic the effect of PAR2 activation, abolishing both JNK activity and phosphorylation.
Regulation (effect) of Positive_regulation (activation) of PAR2
1) Confidence 0.37 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.12
Initially, we found that we could mimic the inhibitory effect of PAR2 activation with PMA and that this effect could be reversed by micromolar concentrations of the PKC inhibitor, GF109203X, thereby implicating the involvement of PKC isoforms (Fig. 5, Panel A).
Regulation (effect) of Positive_regulation (activation) of PAR2
2) Confidence 0.37 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.11
Interestingly, the predominant effect of PAR-2 activation over IL-1?
Regulation (effect) of Positive_regulation (activation) of PAR-2
3) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.00 Pain Relevance 0.57
For these reasons we have used a microarray approach, with two structurally and mechanistically different PAR2 agonists, to clearly establish effects of PAR2 activation on human gene expression.
Regulation (effects) of Positive_regulation (activation) of PAR2 associated with agonist
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.67 Pain Relevance 0.31

General Comments

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