INT22450

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 31
Total Number 36
Disease Relevance 18.77
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (GPI) small molecule metabolic process (GPI) carbohydrate metabolic process (GPI)
cytoplasm (GPI) cytosol (GPI) extracellular space (GPI)
Anatomy Link Frequency
T-cell 2
plasma 1
dorsal 1
bone marrow 1
impression 1
GPI (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 316 100.00 Very High Very High Very High
Somatostatin 12 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Cholecystokinin 9 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Thalamus 157 99.84 Very High Very High Very High
headache 34 99.78 Very High Very High Very High
Arthritis 55 99.40 Very High Very High Very High
rheumatoid arthritis 139 98.56 Very High Very High Very High
Neuropeptide 15 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 1422 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 96 100.00 Very High Very High Very High
Disease 938 99.80 Very High Very High Very High
Headache 34 99.78 Very High Very High Very High
Hematological Disease 126 99.66 Very High Very High Very High
Arthritis 60 99.40 Very High Very High Very High
Rheumatoid Arthritis 139 98.56 Very High Very High Very High
Aplastic Anemia 135 98.44 Very High Very High Very High
Nociception 1 98.20 Very High Very High Very High
Congenital Anomalies 45 98.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peritoneal exudates from rats that develop arthritis contain a greater proportion of the high TNF producing subclass of M phi, as identified by positive ED3 staining (p < 0.001).
Gene_expression (producing) of phi associated with arthritis
1) Confidence 0.58 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9585810 Disease Relevance 1.06 Pain Relevance 0.53
The headache eliciting effects of prostacyclin (prostaglandin I(2), (PGI(2))) and its possible mechanisms had previously not been systematically studied in man.
Spec (possible) Gene_expression (effects) of PGI associated with headache
2) Confidence 0.52 Published 2008 Journal Pain Section Abstract Doc Link 18450380 Disease Relevance 0.52 Pain Relevance 0.34
A simpler way to infer such correlation in practice would be to estimate spectral concentration in GPi local field potentials, and this is directly observable from an ordinary DBS electrode placed within the GPi.
Gene_expression (electrode) of GPi associated with deep brain stimulation
3) Confidence 0.43 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.07 Pain Relevance 0.17
Now, simultaneously provide the cell with excessive inhibition, such as in Parkinson’s disease, from an overactive GPi.
Gene_expression (overactive) of GPi associated with disease
4) Confidence 0.43 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.10 Pain Relevance 0
One could similarly record the average GPi output from a DBS electrode in GPi and reconstruct the estimated TC-cell activity.
Gene_expression (electrode) of GPi associated with deep brain stimulation
5) Confidence 0.43 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.07 Pain Relevance 0.05
One could similarly record the average GPi output from a DBS electrode in GPi and reconstruct the estimated TC-cell activity.
Gene_expression (electrode) of GPi associated with deep brain stimulation
6) Confidence 0.43 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.07 Pain Relevance 0.05
We can now relatively safely place electrodes in the STN, GPi or thalamus.9
Gene_expression (electrodes) of GPi in thalamus associated with thalamus
7) Confidence 0.43 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.55 Pain Relevance 0.17
Adding to this list, it has now been reported that expression of a T-cell receptor encoding for glucose-6-phosphate isomerase (GPI) will lead to arthritis through the production of antibodies specific for the same antigen [30].
Gene_expression (expression) of GPI in T-cell associated with arthritis
8) Confidence 0.34 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129997 Disease Relevance 1.33 Pain Relevance 0.41
Uses and limitations of the new GPI model
Gene_expression (model) of GPI
9) Confidence 0.30 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129997 Disease Relevance 1.28 Pain Relevance 0.46
The conformers differ in the values of neighboring psi and phi dihedral angles, since such psi/phi compensation can still produce the same end-to-end distance.
Gene_expression (produce) of phi
10) Confidence 0.29 Published 2007 Journal J Phys Chem B Section Abstract Doc Link 17918879 Disease Relevance 0 Pain Relevance 0.23
Efficacy measures involved pain (numeric rating scale, McGill pain questionnaire), movement disorders (Burke-Fahn-Marsden dystonia rating scale, unified myoclonus rating scale, tremor research group rating scale), activity (Radboud skills questionnaire, walking ability questionnaire), and a clinical global impression (CGI) and patient's global impression score (PGI).
Gene_expression (impression) of PGI in impression associated with tremor, movement disorders, pain, myoclonus and dystonia
11) Confidence 0.27 Published 2009 Journal Pain Section Abstract Doc Link 19683392 Disease Relevance 1.42 Pain Relevance 0.85
Neither the STN nor the GPi DBS improves the “on” medication function.
Gene_expression (improves) of GPi associated with deep brain stimulation
12) Confidence 0.14 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.59 Pain Relevance 0.36
In this mouse model system, GPI can serve as an autoantigen for both B and T cells, and passive transfer of anti-GPI to normal healthy animals induces arthritis.
Gene_expression (transfer) of anti-GPI in T cells associated with arthritis
13) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 1.16 Pain Relevance 0.46
We concurrently measured, by radioimmunoassay, levels of substance P (SP), somatostatin (SST), methionine-enkephalin (Met-Enk), cholecystokinin (CCK), peptide hystidyl-isoleucine (PHI), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) in the ventral and dorsal gray matter at each segment of the cervical, thoracic, lumbar, and sacral spinal cord, obtained within 6 hours of death from 4 subjects (ages 17 to 55) with no neurologic disease.
Gene_expression (levels) of PHI in ventral associated with somatostatin, enkephalin, disease, spinal cord, neuropeptide, cholecystokinin, substance p and death
14) Confidence 0.08 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.18 Pain Relevance 0.65
PHI, VIP, and NPY were significantly higher in lumbar and especially sacral cord than in cervical and thoracic segments.
Gene_expression (higher) of PHI in thoracic segments
15) Confidence 0.08 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.18 Pain Relevance 0.78
By this technique, one or two RBC populations with abnormal expression of GPI-APs may be shown in PNH patients: one completely lacking GPI-AP expression (type III PNH cells), and another characterized by GPI-AP faint (dim) expression (type II PNH cells).
Gene_expression (expression) of GPI associated with paroxysmal nocturnal hemoglobinuria
16) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.77 Pain Relevance 0.06
The first GPI-anchor structure determination, as well as the first description of the mechanism of GPI biosynthesis were both established using trypanosome VSG [136, 144–146].
Gene_expression (biosynthesis) of GPI
17) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0 Pain Relevance 0
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Gene_expression (composed) of GPI associated with disorder of lipid metabolism
18) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0
This GPI-anchor is preassembled as a GPI precursor with the following structure: NH2CH2CH2-PO4H-6Man?
Gene_expression (precursor) of GPI
19) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0 Pain Relevance 0
By contrast, phenotypically abnormal PNH CD34+ (GPI-AP negative) showed a gene expression profiling closer to that obtained in CD34+ cells from healthy individuals (Chen et al 2005).
Gene_expression (abnormal) of GPI associated with paroxysmal nocturnal hemoglobinuria
20) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.03 Pain Relevance 0

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