INT224501

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.29
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
plasma 2
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 5 99.56 Very High Very High Very High
metalloproteinase 41 98.94 Very High Very High Very High
Inflammatory response 11 98.90 Very High Very High Very High
Kinase C 6 98.48 Very High Very High Very High
Osteoarthritis 146 98.28 Very High Very High Very High
Inflammation 234 95.28 Very High Very High Very High
chemokine 8 93.40 High High
cytokine 73 92.84 High High
Dopamine 83 72.24 Quite High
Arthritis 13 66.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 233 98.70 Very High Very High Very High
Osteoarthritis 147 98.28 Very High Very High Very High
Cancer 107 94.80 High High
Metastasis 4 93.84 High High
Necrosis 16 92.08 High High
Inflammatory Bowel Disease 51 88.56 High High
Death 10 85.52 High High
Apoptosis 165 85.28 High High
Disease 46 81.84 Quite High
Mycobacterial Infection 1 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific PAR-2 activation stimulates major pathophysiological pathways involved in the OA process, including MMP-1 and MMP-13 as well as cyclooxygenase 2 (COX-2), through the activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and p38.


Positive_regulation (activation) of Gene_expression (/) of Erk1 associated with metalloproteinase, cox2 and osteoarthritis
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.27 Pain Relevance 0.69
It is not entirely clear how this works, but the most likely model is that the innate immune responses, initiated by direct activation of ERK1/2, release endogenous ligands that signal via a receptor coupled to MyD88, and for full immune activation also act via TLR2.
Positive_regulation (activation) of Gene_expression (/) of ERK1
2) Confidence 0.49 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.13 Pain Relevance 0.19
1-integrin, Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (/) of ERK 1
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.13 Pain Relevance 0
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Positive_regulation (activation) of Gene_expression (/) of ERK 1
4) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9 (Figure 3C).
Positive_regulation (activated) of Gene_expression (/) of ERK 1
5) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.36 Pain Relevance 0
1-integrin was upregulated and Shc, activated ERK 1/2 and the chondrogenic specific transcription factor Sox-9 was highly expressed in MSC cultures treated with IL-1?
Positive_regulation (activated) of Gene_expression (/) of ERK 1
6) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.30 Pain Relevance 0.03
induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-?
Positive_regulation (activation) of Gene_expression (kinases) of ERK in plasma associated with inflammatory response
7) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2996791 Disease Relevance 0.89 Pain Relevance 0.23
Several mechanisms of action might be relevant for the biological activity of VPA: (1) VPA increases the DNA binding ability of activating protein-1 (AP-1) transcription factor, and the expression of genes regulated by the extracellular-regulated kinase (ERK)-AP-1 pathway; (2) VPA downregulates protein kinase C (PKC) activity; (3) VPA inhibits GSK3?
Positive_regulation (increases) of Gene_expression (expression) of ERK associated with kinase c
8) Confidence 0.45 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.92 Pain Relevance 0.14
Differentiation increased expression of EPHB2 and EPHB3.
Positive_regulation (increased) of Gene_expression (expression) of EPHB2
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13

General Comments

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